Rick Baker

Assistant Professor

Assistant Professor
Community Engagement Committee Chair – Curriculum and Scholarship

(PhD – Princeton Univ.)

ACCEPTING STUDENTS

RESEARCH TOPICS

structural biology, membrane trafficking, cancer biology, cryo-EM methods development. Our research aims to understand the molecular mechanisms of membrane trafficking.

We use the tools of cryo electron microscopy (cryo-EM) to study how protein complexes assemble on membranes to bud and fuse vesicles. Specialties: cryo-EM, X-ray crystallography, biochemistry, protein purification.

RESEARCH

A hallmark of eukaryotic cell biology is a complex and dynamic organellar architecture. The process of forming and maintaining this architecture requires a regulated cycle of budding and fusion events and is broadly called membrane trafficking. The Baker lab is interested in understanding the machines that catalyze and regulate membrane trafficking events, with a particular focus on studying systems in their native, membrane-bound state.

A primary focus of the Baker lab is a membrane trafficking event called endocytosis, which allows cells to constantly modulate the composition of their plasma membrane. As cells communicate with their environment through their plasma membrane, precise control of its structure and composition underpins many processes including signaling, synaptic transmission, and host-pathogen interactions. There is emerging evidence that subversion of membrane traffic at the cell surface is a hallmark of many human diseases. In particular, misregulation of signaling proteins at the cell surface (TGF-beta receptor, etc.) may play a pivotal role in cancer development and progression. The Baker lab is interested in understanding the molecular underpinnings of disease, notably cancer, and is a member of the Lineberger Comprehensive Cancer Center (LCCC).

In the Baker lab, we use a variety of techniques to understand these systems in molecular detail, including high-resolution cryo-EM, X-ray crystallography, single-molecule TIRF, and biochemical reconstitution. We are also involved in cryo-EM methods development centered on novel methods for high-resolution structures of membrane-bound proteins, and novel grid supports to overcome resolution limitations of challenging samples. Additionally, we collaborate with several groups that use a variety of model systems, including Saccharomyces and C. elegans, and experimental approaches like unbiased genetic screens, fitness assays, and live cell microscopy, enabling us to study these systems in a highly interdisciplinary and collaborative manner.

The Baker lab is committed to providing a safe and inclusive training environment that celebrates the diverse backgrounds, viewpoints, and contributions of all lab members.