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Brian Strahl

Interim Chair

Research: Histone modifications and epigenetics; Core Techniques: yeast genetics, peptide synthesis, peptide arrays, mammalian cell culture

Oliver Smithies investigator, Professor and Interim Chair
Diversity Committee Member
Faculty Director, UNC High-throughput Peptide Synthesis and Array Facility
Co-Director of Chromatin and Epigenetics Program
(PhD – NC State University)

ACCEPTING STUDENTS

Trained Faculty Mentor endorsed by Office of Graduate Ed UNC Chapel Hill

HONORS & AWARDS

  • UNC Excellence in Basic Science Mentoring Award 2019
  • UNC Oliver Smithies Investigator: 2018
  • NIH Maximizing Investigators’ Research Award (MIRA), National Institute of General Medical Sciences: 2018
  • Philip & Ruth Hettleman Prize: 2009
  • NIH Eureka Award: 2008
  • Schering-Plough Research Institute Award: 2004
  • Presidential Early Career Award for Scientists and Engineers: 2003
  • Pew Scholar: 2003

RESEARCH SUMMARY

Eukaryotic genomes are packaged into the nuclei of cells through the actions of histone proteins. These proteins not only play a role in condensing the genome but are fundamental to establishing and maintaining chromatin domains such as euchromatin and heterochromatin. Our lab is addressing how chromatin organization achieved and what factors make the underlying DNA permissive to the protein machineries that drive transcription, replication, recombination, and repair. A large body of work shows that histone post-translational modifications are central to the regulation of chromatin structure and function. These modifications, which include acetylation and methylation, decorate histones and function, at least in part, by recruiting chromatin regulatory proteins to the sites of these modifications. Current efforts are aimed at understanding how histone modifications are installed and removed, and how they are interpreted to regulate genome function.

SELECTED PUBLICATIONS (2016-2021)

2021

Yoblinski, A. R., Forester, K., E., Chung, S., Robinson, Strahl, B. D.* & Dronamraju, R.* Catalysis-Dependent and Redundant Roles of Dma1 and Dma2 in Maintenance of Genome Stability in Saccharomyces cerevisiae. J Biol Chem. doi: 10.1016/j.jbc.2021.100721.

Ren, W., Fan, H., Grimm, S., Kim, J. J., Li, L., Guo, Y., Petell, C. Tan, X.-F., Zhnag, Z.-M., Coan, J., Yin, J., Kim, D. I., Gao, L., Cai, L., Khudaverdyan, N. N., Cetin, B., Patel, D., Wang, Y., Cui, Q., Strahl, B. D. , Gozani, O., Miller, K., O’leary, S., Wade, P., Wang, G. G. & Song, J. (2021) DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation. Nature Communications. 12:2490.

Jain, K & Strahl, B. D. (2021) Oncohistones: corruption at the core. Nature Chemical Biology. 17:370-371.

Slaughter, M. J., Shanle, E. K., Khan, A., Chua, K. F., Hong, T., Boxer, L. D., Allis, C. D., Josefowicz, S. Z., Garcia, B. A., Rothbart, S. B, Strahl, B. D.* & Davis, I. J.* (2021) HDAC inhibitors result in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies. Cell Reports. 34:108638.

 

2020

Braberg, H., Echeverria, I, Bohn, S., Cimermancic, P., Shiver, A., Alexander, R., Xu, J., Shales, M., Dronamraju, R., Jiang, S., Dwivedi, G., Bogdanoff, D., Chaung, K. K., Huettenhain, R., Wang, S., Mavor, D., Pellarin, R., Schneidman, D., Bader, J. S., Fraser, J. S., Morris, J., Haber, J. E., Strahl, B. D., Gross, C. A., Dai, J., Boeke, J., Sali, A & Krogan, N. J. (2020) Genetic interaction mapping informs integrative structure determination of protein complexes. Science. doi: 10.1126/science.aaz4910.

Fan, H., Lu, J., Guo, Y., Li, D., Zhang, Z., Tsai, Y-H., Pi, W-C., Ahn. J. H., Gong, W., Xiang, Y., Allison, D. F., Geng, H., He, S., Diao, Y., Chen, W.-Y., Strahl, B. D. , Cai, L. Song, J. & Wang, G. G. (2020) BAHCC1 couples H3K27me3 to gene silencing and tumorigenesis via a conserved BAH module. Nature Genetics. 52:1384-1396.

Tencer, A. H., Cox, K. L., Wright, G. M., Zhang, Y., Klein, B. J., Petell, C. J., Strahl, B. D., Black, J. C., Poireir, M. G. & Kutateladze, T. G. (2020) Molecular mechanism of the MORC4 ATPase activation. Nature Communications. 11:5466.

Vaughan, R. M., Kupai, A., Foley, C. A., Sagum, C. A., Tibben, B. M., Eden, H. E., Tiedemann, R. L., Berryhill, C. A., Patel, V., Shaw, K., M., Krajewski, K., Strahl, B. D., Bedford, M., T., Frye, S., V., Dickson, B. D. & Rothbart, S., B. (2020) The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells. Epigenetics & Chromatin. 13:44.

Lerner, A. M.*, Hepperla, A. J.*, Keele, G. R.*, Meriesh, H., Yumerefendi, H., Restrepo, D., Zimmerman, S., Bear, J., Kuhlman, B., Davis, I. J.* & Strahl B. D.* (2020) An optogenetic switch for the Set2 methyltransferase provides evidence for rapid transcription-dependent and independent dynamics of H3K36 methylation. Genome Research. 30:1605-1617.

Ren, W., Fan, H., Grimm, S. A., Guo, Y., Kim, J. J., Li, L., Petell, C. J., Tan, X.-F., Zhang, Z.-M., Coan, J. P., Gao, L., Cai, L., Detrick, B., Cetin, B., Cui, Q., Strahl, B. D., Gozani, O., Wang, Y., Miller, K. M., O’leary, S., Wade, P. A., Wang, G. G. & Song, Jikui. (2020) Direct readout of heterochromatin H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. Proc Natl Acad Sci. doi: 10.1073/pnas.2009316117.

Strahl, B. D. & Briggs S. D. (2020) The SAGA continues: The rise of cis- and trans-histone crosstalk pathways. Biochim Biophys Acta Gene Regul Mech. doi: 10.1016/j.bbagrm.2020.194600.

DiFiore, J. V., Ptacek, T. S., Li, B., Simon, J. M. & Strahl, B. D. (2020) Unique and Shared Roles for Histone H3K36 Methylation States in Transcription Regulation Functions. Cell Reports.31:107751.

Turner, A.-M., Dronamraju, R., Potjewyd, F. M., Sholtis, K., M., Winecoff, D. K., Kirchherr, J. L., Archin, N. M., Browne, E. P., Strahl, B. D., James, Lindsey, I & Margolis, D. M. (2020) Evaluation of EED Inhibitors as a New Class of PRC2-Targeted Small Molecules for HIV Latency Reversal. ACS Infectious Diseases. doi: 10.1021/acsinfecdis.9b00514.

Meriesh, H. A., Lerner, A. M., Chandrasekharan, M. B. & Strahl, B. D. (2020) The histone H4 basic patch regulates SAGA-mediated H2B deubiquitination and histone acetylation. J Biol Chem. 295:6561-6569.

Jian, K., Frase, C. S., Marunde, M., Parker, M. M., Sagum, C., Burg, J., Hall, N., Popov, I., Rodriguez, K., Vadiya, A., Krajewski, K., Keogh, M.-C., Bedford, M. T*. & Strahl, B. D.* (2020) Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions. Epigenetics & Chromatin. 13:3.

2019

Gowans, G. J., Bridgers, J. B., Zhang, J., Dronamraju, R., Burnetti, A., King, D. A., Thiengmany, A. V., Shinsky, S. A., Bhanu, N. V., Garcia, B. A., Buchler, N. E., Strahl, B. D.* & Morrison, A. J.* (2019) Recognition of histone crotonylation by Taf14 links metabolic state to gene expression. Molecular Cell.76:909-921.

Albanese, K. I.*, Krone, M. W.*, Petell, C. J.*, Parker, M. M., Strahl B. D., Brustad, E. M. & Waters, M. L. (2019) Engineered reader proteins for enhanced detection of methylated lysine on histones. ACS Chem Biol. doi: 10.1021/acschembio.9b00651.

Li, T.M., Coan, J. P., Krajewski, K., Zhang, L., Elias, J. E., Strahl, B. D., Gozani, O & Chua, KF. (2019) Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules. Sci Rep. 9:14226.

Klein, B. J., Jang, S. M., Lachance C., Mi, W., Sakuraba, S., Krajewski, K., Lyu, J., Wang, W. W., Sidoli, S., Yan, K., Liu, J., Zhang, Y., Roques, C., Fournier, E., Wang, X., Warfield, B. M., Yang, X.0J., Garcia, B. A., Liu, W. R., Li, W., Strahl, B. D., Kono, H., Shi, X., Cote, J. & Kutateladze. (2019) Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation. Nature Commun. 10:4724.

Zhang, Y., Jang, Y., Lee, J.-E., Ahn, J., Xu, L., Holden, M. R., Cornett, E. M., Krajewski, K., Klein, B. J., Wang, S.-P., Dou, Y., Roeder, R. G., Strahl, B. D., Rothbart, S. B., Shi, X., Ge, K. & Kutateladze, T. G. (2019) Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.  Nature Commun. 10:2314.

Petell, C. J., Pham, A. T., Skela, J. & Strahl, B. D. Improved methods for the detection of histone interactions with peptide microarrays.  Sci Rep. 9:6265.

Noubouossie D. F., Reeves, B. N., Strahl, B. D. & Key, N. S. (2019) Neutrophils: back in the thrombosis spotlight. Blood doi: 10.1182/blood-2018-10-862243.

Armstrong, R. L., Penke, T. J. R., Chao, S. K., Gentile, G. M., Strahl, B. D., Matera, A. G., McKay, D. J. & Duronio, R. J. (2019) H3K9 promotes under-replication of pericentromeric heterochromatin in Drosophila salivary gland polytene chromosomes. Genes. 10(2) E93.

Leatham-Jensen, M., Uyehara, C. M., Strahl, B. D., Matera, A. G., Duronio, R. J. & McKay, D., J. (2019) Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation. PLoS Genet. 15:e1007932.

2018

Dranamraju, R., Kerschner, J. L., Peck, S. A., Patel, D., Aslam, S., Mosley, A. L. & Strahl, B. D. (2018) Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction.  Cell Reports. 25:3476-3489.

Lerner, A. M., Yumerefendi, H., Goudy, O. J., Strahl, B. D. & Kuhlman K. (2018) Engineering improved photoswitches for the control of nucleocytoplasmic distribution.  ACS Synthetic Biology.0.1021/acssynbio.8b00368.

Klein, B.J.,Vann, K. R., Andrews, F. H., Wang, W. W, Zhang, J., Zhang, Y., Beloglazkina, A. A., Mi, W., Li, Yuanyuan, Li., H., Shi, X., Kutateladze, A. G., Strahl, B. D., Liu, W. R. & Kutateladze, T. G. (2018) Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain. Nature Commun. 9:4574.

Klein, B.J., Krajewski, K., Restrepo, S., Lewis, P. W.*, Strahl, B. D.* & Kutateladze, T. G.* (2018) Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers. Epigenetics. doi: 10.1080/15592294.2018.1503491.

Slaughter, M. J., Shanle, E. K., McFadden, A. W., Suttle, L. E., Strahl, B. D. & Davis, I. J. (2018) Polybromo-1 (PBRM1) bromodomains variably influence nucleosome interactions and cellular function. J Biol Chem. doi: 10.1074/jbc.RA118.003381.

Dronamraju, R., Hepperla, A. J., Shibata, Y., Adams, A. T., Magnuson, T., Davis, I. J. & Strahl, B. D.(2018) Spt6 association with RNA Polymerase II directs mRNA turnover during transcription. Molecular Cell. 70:1054-1066.

Chiang, Y. C., Park, I. Y., Terzo, E. A., Tripathi, D. N., Mason, F. M., Fahey, C. C., Karki, M., Shuster, C. B., Sohn, B., H., Chowdhary, P., Powell, R. T., Ohi, R., Tsai, Y. S., de Cubas, A. A., Khan, A., Davis, I. J., Strahl, B. D., Parker, J. S., Dere, R., Walker, C. L. & Rathmell, W. K. (2018) SET2 haploinsufficiency for microtubule methylation is an early driver of genomic instability in renal cell carcinoma. Cancer Research. 78:3135-3146.

Suh, J. L., Watts, B., Stuckey, J. I., Norris-Drouin, J. L., Cholensky, S. H., Dickson, B. M., An, Y., Mathea, S., Knapp, S., Khan, A., Adams, A. T., Strahl, B. D., Sagum, C., Bedford, M. T., James, L. I., Kireev, D. B. & Frye, S. V. (2018) Quantitative characterization of bivalent probes for a dual bromodomain protein, Transcription Initiation Factor TFIID subunit 1. Biochemistry. 57:2140-2149.

Meers, M. P., Aldemna, K., Duronio, R. J., Strahl, B. D., McKay, D. J. & Matera, A. G. (2018) Transcription start site profiling uncovers divergent transcription and enhancer-associated RNAs in Drosophila melanogaster. BMC Genomics. 19:157.

Dronamraju, R., Jha, D., Eser, E., Dominguez, D., Adams, A., Choudhury, R., Chiang, Y. C., Rathmell, W. K., Emanuele, M. J., Churchman, L. S. & Strahl, B. D. (2018) Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity. Nucleic Acids Research. 46:1331-1334.

Klein, B. J., Ahmad, S., Vann, K. R., Andrews, F. H., Mayo, Z. A., Bourriquen, G., Bridgers, J. B., Zhang, J., Strahl, B. D., Cote, J. & Kutateladze, T. G. (2018) Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain. Nucleic Acids Research. 46:421-430.

Penke, T., McKay, D. J., Strahl, B. D., Matera, A. G. & Duronio, R. J. (2018) Functional redundancy of variant and canonical histone H3 lysine 9 modification in Drosophila. Genetics. 208:229-244.

2017

Veland, N., Zhong, Y., Gayatri, S., Dan, J, Strahl, B. D., Rothbart, S. B., Bedford, M. T. & Chen T. The arginine methyltransferase PRMT6 regulates DNA methylation and contributes to global DNA hypomethylation in cancer. Cell Reports. 21:3390-3397.

Tencer, A. H., Cox, K. L., Di, L., Bridgers, J. B., Lyu, J., Wang, X., Sims, J. K., Weaver, T. M., Allen, H. F., Zhang, Y., Gatchalian, J., Darcy, M. A., Gibson, M. D., Ikebe, J., Li, W., Wade, P. A., Hayes, J. J., Strahl, B. D., Kono, H., Poirier, M. G., Musselman, C. A. & Kutateladze, T. G. (2017) Covalent modification of histone H3K9 promotes binding of CHD3. Cell Reports. 21:455-466.

Dronamraju, R.*, Ramachandran, S.*, Jha, D. K.*, Adams, A. T., DiFiore, J. V., Parra, M. A., Dokholyan, N. V.* & Strahl, B. D.* (2017) Redundant functions for Nap1 and Chz1 in H2A.Z deposition. Scientific Reports. 7:10791.

Tencer, A. H., Gatchalian, J., Klein, B. J., Khan, A., Zhang, Y., van Wely, K. H. M., Strahl, B. D. & Kutateladze, T. G. (2017) A unique pH-dependent recognition of methylated histone H3K4 by PPS and DIDO3. Structure. 25:1530-1539.

McDaniel, S. L., Hepperla, A., Huang, Jie, Kulkarni, V. G., Davis, I. J. & Strahl, B. D. (2017) H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity. Cell Reports. 19:2371-2382

McDaniel, S. L. & Strahl, B. D. (2017) Shaping the Cellular Landscape with Set2/SETD2 methylation. Cellular & Molecular Life Sciences. doi: 10.1007/s00018-017-2517-x.

Khan, A., Bridgers, J. S. & Strahl, B. D. (2017) Expanding the reader landscape of histone acylation. Structure. 25:571-573.

Meers, M., P., Henriques, T., Lavender, C. A., McKay, D. J., Strahl, B. D., Duronio, R. J., Adelman, K. & Matera, A. G. (2017) Histone replacement decouples H4 acetylation from cryptic transcription in H3K6 mutants and reveals a post-transcriptional mechanism for maintaining transcriptome fidelity in animals. ELife. pii: e23249. doi: 10.7554/eLife.23249.

Shanle, E. K.*, Shinsky, A. A.*, Bridgers, J. B., Bae, N., Sagum, C., Krajewski, K., Rothbart, S. B., Bedford, M. T.* & Strahl, B. D.* (2017) Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics & Chromatin. 10:12 doi: 10.1186/s13072-017-0117-5.

2016

Savitsky, P., Krojer, T., Fujisawa, T., Lambert, J.P., Picaud, S., Wang, C.Y., Shnale, E. K., Krajewski, K., Friedrichsen, H., Kanapin, A., Goding, C., Schapira, M., Samsonova, A., Strahl, B. D., Gingras, A.C. & Filippakopoulos, P. (2016) Multivalent histone and DNA engagement by a PHD/BRD/PWWP triple reader cassette recruits ZMYND8 to K14ac-rich chromatin. Cell Reports. 17:2724-2737.

Strikoudis, A., Lazaris, C., Trimarchi, T., Galvao Neto, A. L., Yang, Y., Ntziachristos, P., Rothbart, S. D., Buckley, S., Dolgalev, I., Stadtfeld, M., Strahl, B. D., Dynlacht, B. D., Tsirigos, A & Aifantis, I. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nature Cell Biology. doi: 10.1038/ncb3424.

Charpentier, T. H., Waldo, G. L., Lowery-Gionta, E. G., Krajewski, K., Strahl, B. D., Kash, T. L., Harden, K. & Sondek, J. Potent and selective peptide-based inhibition of Gαq. Journal of Biological Chemistry. pii: jbc.M116.740407.

Andrews, F. H., Tong, Q., Sullivan, K. D., Cornett, E., Zhang, Y., Muzaffar, A., Ahn, J., Strahl, B. D., Costello, J. C., Espinosa, J. M., Rothbart, S., B. & Kutateladze, T. G. (2016) Multivalent chromatin engagement and inter-domain crosstalk regulate MORC3 ATPase. Cell Reports. 16:3195-31207.

Harrison, J. S., Cornett, E. M., Goldfarb, D., DaRosa, P. A., Li, Z. M., Yan, F., Dickson, B. M., Guo, A. H., Cantu, D. V., Kaustov, L., Brown, P. J., Arrowsmith, C. H., Klevit, R. E., Erie, D. A., Major, M. B., Krajewski, K., Kuhlman, B., Strahl, B. D. & Rothbart, S. B. (2016) Hemi-methylated DNA regulates DNA methylation inheritance through allosteric control of H3 ubiquitylation by UHRF1. ELife. http://dx.doi.org/10.7554/eLife.17101.001

Penke, T. J. R., McKay, D. J., Strahl, B. D., Matera, A. G & Duronio, R. J. (2016) Direct interrogation of the role of H3K9 in metazoan heterochromatin function. Genes & Development. 30:1866-1880.

Chen, H., Workman, J. J., Strahl, B. D. & Laribee, R. N. (2016) Histone H3 and TORC1 Prevent Organelle Dysfunction and Cell Death by Promoting Nuclear Retention of HMGB Proteins. Epigenetics & Chromatin. 9:34

Hacker, K. E.*, Fahey, C. C.*, Shinsky, S. A.*, Chiang, Y.-C. J.*, DiFiore, J. V.*, Jha, D. K., Vo, A. H., Shavit, J. A. Davis, I, J., Strahl, B. D.* & Rathmell, W. K.* (2016) Structure/Function Analysis of Recurrent Mutations in SETD2 Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and H3K36 Trimethylation. Journal of Biological Chemistry. Aug 15. pii: jbc.M116.739375.

Andrews, F. H., Strahl, B. D. & Kutateladze, T. G. (2016) Insights into newly discovered marks and readers of epigenetic information. Nature Chemical Biology. 12:662-668.

Cornett, E. M., Dickson, B. M., Vaughan, R. M., Trievel, R. C., Strahl, B. D. & Rothbart, S. B. (2016) Substrate specificity profiling of histone-modifying enzymes by peptide microarray. Methods in Enzymology. 574:31-52.

McDaniel, S. L., Fligor, J. E., Chun, R., Cui, H., Bridgers, J. B., DiFiore, J. V., Guo, A. H., Li, B. & Strahl, B. D. (2016) Combinatorial Histone Readout by the Dual Plant Homeodomain (PHD) Fingers of Rco1 Mediates Rpd3S Chromatin Recruitment and the Maintenance of Transcriptional Fidelity. Journal of Biological Chemistry. 291:14796-14802.

Bedard, L. G., Dronamraju, R., Kerschner, J.L., Hunter, G.O., Axley, E.D., Boyd, A.K., Strahl, B.D. & Mosley, A.L. (2016) Quantitative analysis of dynamic protein interactions during transcription reveals a role for casein kinase II in PAF complex phosphorylation and regulation of H2B monoubiquitylation. Journal of Biological Chemistry. 291:13410-13420.

Yumerefendi, H., Lerner, A. M., Zimmerman, S. P., Hahn, K., Bear, J. E., Strahl, B. D. & Kuhlman, B. (2016) Light-induced nuclear export reveals rapid dynamics of epigenetic marks. Nature Chemical Biology. 12:399-401.

Andrews, F. H.*, Shinsky, A. S.*, Shanle, E. K., Bridgers, J. B., Gest, A., Tsun, I. K., Krajewski, K., Shi, X., Strahl, B. D.* & Kutateladze, T. G.* (2016) The Taf14 YEATS domain is a reader of histone crotonylation. Nature Chemical Biology. 12:396-398.

Gatchalian, J., Mora, C., Shinsky, S. A., Ospina, R. R., Mansilla, A. L., Klein, B. J., Andrews, F. H., Strahl, B. D., van Wely, K. H. M. & Kutateladze, T. G. (2016) Chromatin condensation and recruitment of PHD fingers to histone H3K4me3 are mutually exclusive. Nucleic Acids Research. Mar 25. pii: gkw193.

Sorenson, M. R., Jha, D. K., Ucles, S., Flood, D., Strahl, B. D., Stevens, S. W. & Kress, T. L. (2016) Histone H3K36 methylation regulates pre-mRNA splicing in Saccharomyces cerevisiae. RNA Biology. 13:412-426.

Hattori, T., Lai, D., Dementieva, I. S., Montano, S. P., Zheng, Y., Akin, L., Swift, K., M., Grzybowski, A. T., Koide, A., Krajewski, K., Strahl, B. D., Kelleher, N. L., Ruthenburg, A. J. & Koide, S. (2016) Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation. Proc Natl Acad Sci USA.113:2092-2097.

Andrews, F. H.*, Shanle, E. K.*, Strahl, B. D.* & Kutateladze, T. G.* (2016) The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation. Transcription. 7:14-20.

Andrews, F. H., Gatchalian, J., Krajewski, K., Strahl, B. D. & Kutateladze, T. G. (2016) Regulation of methyllysine readers through phosphorylation. ACS Chemical Biology. 7:14-20.

Shanle, E. K., Tsun, I. K. & Strahl, B. D. (2016) A course-based undergraduate research experience investigating p300 bromodomain mutations. Biochemistry and Molecular Biology Education. 44:68-74.

Link to all pubs


Brian Strahl

  • Biochemistry & Biophysics