Oliver Smithies investigator, Professor and Interim Chair
Diversity Committee Member
Faculty Director, UNC High-throughput Peptide Synthesis and Array Facility
Co-Director of Chromatin and Epigenetics Program
(PhD – NC State University)
ACCEPTING STUDENTS
HONORS & AWARDS
- UNC Excellence in Basic Science Mentoring Award, 2019
- UNC Oliver Smithies Investigator, 2018
- NIH Maximizing Investigators’ Research Award (MIRA), National Institute of General Medical Sciences, 2018
- Philip & Ruth Hettleman Prize, 2009
- NIH Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) award, 2008
- Jefferson-Pilot Fellow in Academic Medicine, UNC, 2006
- North Carolina State University Outstanding Alumnus Award, 2005
- Schering-Plough Research Institute Award, 2004
- Presidential Early Career Award for Scientists and Engineers (PECASE), 2003
- Pew Scholar (Pew Scholars Program in the Biomedical Sciences), 2003
RESEARCH
SELECTED PUBLICATIONS
2021
Mechanically transduced immunosorbent assay to measure protein-protein interactions. Petell CJ, Randene K, Pappas M, Sandoval D, Strahl BD, Harrison JS, Steimel JP.Elife. 2021 Sep 28;10:e67525. doi: 10.7554/eLife.67525.
Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14. Enríquez P, Krajewski K, Strahl BD, Rothbart SB, Dowen RH, Rose RB.J Biol Chem. 2021 Oct;297(4):101145. doi: 10.1016/j.jbc.2021.101145. Epub 2021 Aug 30.
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation. Ren W, Fan H, Grimm SA, Kim JJ, Li L, Guo Y, Petell CJ, Tan XF, Zhang ZM, Coan JP, Yin J, Kim DI, Gao L, Cai L, Khudaverdyan N, Çetin B, Patel DJ, Wang Y, Cui Q, Strahl BD, Gozani O, Miller KM, O’Leary SE, Wade PA, Wang GG, Song J.Nat Commun. 2021 May 3;12(1):2490. doi: 10.1038/s41467-021-22665-4.
Yoblinski, A. R., Forester, K., E., Chung, S., Robinson, Strahl, B. D.* & Dronamraju, R.* Catalysis-Dependent and Redundant Roles of Dma1 and Dma2 in Maintenance of Genome Stability in Saccharomyces cerevisiae. J Biol Chem. doi: 10.1016/j.jbc.2021.100721.
Ren, W., Fan, H., Grimm, S., Kim, J. J., Li, L., Guo, Y., Petell, C. Tan, X.-F., Zhnag, Z.-M., Coan, J., Yin, J., Kim, D. I., Gao, L., Cai, L., Khudaverdyan, N. N., Cetin, B., Patel, D., Wang, Y., Cui, Q., Strahl, B. D. , Gozani, O., Miller, K., O’leary, S., Wade, P., Wang, G. G. & Song, J. (2021) DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation. Nature Communications. 12:2490.
Jain, K & Strahl, B. D. (2021) Oncohistones: corruption at the core. Nature Chemical Biology. 17:370-371.
Slaughter, M. J., Shanle, E. K., Khan, A., Chua, K. F., Hong, T., Boxer, L. D., Allis, C. D., Josefowicz, S. Z., Garcia, B. A., Rothbart, S. B, Strahl, B. D.* & Davis, I. J.* (2021) HDAC inhibitors result in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies. Cell Reports. 34:108638.
Lab Contact
3060 Genetic Medicine
CB #7260
Chapel Hill, NC 27599
Office Phone: 919.843.3896 Lab Phone: 919.843.3935