“Selective ER-Export of Misfolded Secretory Pathway Proteins for Lysosomal Degradation” Host: Sasky Neher ABSTRACT We discovered that a subset of misfolded secretory pathway proteins, including variants of prion protein and amyloid precursor protein, are selectively exported out of the ER by a constitutive and stress-enhanced pathway named RESET. After RESET, these misfolded proteins are subsequently … Read more