Dr Monroe and colleagues published a study on the role of plasma inhibitors in regulating thrombin levels.
Dougald Monroe, professor in the UNC Division of Hematology, and colleagues Allen Ma and Maureane Hoffman published their study on the contribution of four plasma inhibitors in regulating thrombin generation. The work was published in Blood Vessels, Thrombosis, & Hemostasis.
Study findings:
Multiple inhibitors, including antithrombin (AT), heparin cofactor II, α2-macroglobulin, and α1-antitrypsin, contribute to thrombin inhibition in plasma. As AT is lowered, the roles of the other inhibitors become more significant. These inhibitors can completely inhibit thrombin even in the absence of AT. These findings may be relevant for novel therapies that reduce AT levels to rebalance hemostasis in people with hemophilia A or B.
Paper is available:
https://doi.org/10.1016/j.bvth.2025.100088
