My research program is focused on identifying the bidirectional relationship between hemostatic system components and cardiometabolic diseases. Obesity (defined as body mass index >30) currently affects >650 billion adults and >340 million children worldwide. Obesity is characterized by a state of chronic low-grade inflammation and induces qualitative and quantitative changes in hemostatic proteins, resulting in a prothrombotic state. I am interested in the following: 1) Determining the cellular and molecular mechanisms by which fibrin(ogen)-macrophage interactions promote the development of high-fat diet induced obesity and associated pathologies, 2) Determining the role of fibrinolytic system components in the development of obesity and associated pathologies and 3) Elucidating the molecular mechanisms by which obesity and metabolic pathologies exacerbate thrombosis.
Steve Hur
Research Assistant Professor, Department of Pathology and Lab Medicine
