Our research focus is on RNA-binding proteins, particularly on ZFP36L2 (Zinc Finger Protein 36 Like 2). So far, the known function of this protein is to bind to mRNAs containing specific sequences rich in Adenine and Uridine elements (AREs). Upon binding, this interaction triggers mRNA decay, decreasing the expression of these targeted transcripts and consequently protein levels. We created a mouse model lacking ZFP36L2, which intriguingly resulted in severe pancytopenia in the peripheral blood with decreased cellularity at the bone-marrow, resembling Myelodysplastic Syndrome (MDS) at a young age. I aim to integrate our research focus on the RNA field with clinical and basic immunological concepts.
I am an enthusiastic and solid medical scientist, passionate about RNA and hematopoietic stem cells (HSC), an extremely relevant research area of interest of the BRC. Eventually, I aim to improve our transfusion and bone marrow transplant practices based in novel discoveries. Our lab is committed to embrace individuals from all backgrounds and groups, including, but not restricted to those from historically excluded minorities. The diversity of our team creates an inclusive, collegial, supportive-equitable team, sustained by our different backgrounds united towards scientific understanding. We consider the education process as being dynamic and transformative. In ways that that the unforeseen novel knowledge leads a to an empowered society. These are also goals shared by the BRC mission at UNC.
