Education and Experience
BS: Tokyo University of Science, 2009
PhD: The University of Tokyo, 2014
Postdoctoral Fellowship: National Cancer Center Hospital East Japan, 2014
University of North Carolina at Chapel Hill, 2014-2019
Research Associate: University of North Carolina at Chapel Hill, 2019-2021
Research Assistant Professor of Medicine: University of North Carolina at Chapel Hill, 2021-present
Research Interests
My research interest focuses on the mechanisms of cancer-associated thrombosis and bleeding. My primary interest is mechanisms of pancreatic cancer-associated venous thrombosis because pancreatic cancer has one of the highest rates of venous thrombosis. I have found that tumor-derived tissue factor positive extracellular vesicles, neutrophils and neutrophil extracellular traps, and plasminogen activator inhibitor-1 independently contribute to venous thrombosis in mouse models of pancreatic cancer. Another interest is the mechanisms of acute leukemia-associated disseminating intravascular coagulation. I am currently investigating the levels of different biomarkers that reflect activation of coagulation and fibrinolysis, as well as fibrinolysis inhibitors in plasma samples from patients with different types of acute leukemia. I am also developing mouse models of acute leukemia to study the roles of host cells versus leukemia cells and different coagulation and fibrinolysis proteins and their inhibitors in acute leukemia-associated disseminated intravascular coagulation.
Selected Bibliography
Hisada Y, Garratt KB, Maqsood A, Grover SP, Kawano T, Cooley BC, Erlich J, Moik F, Flick MJ, Pabinger I, Mackman N, Ay C. Plasminogen activator inhibitor 1 and venous thrombosis in pancreatic cancer. Blood Adv. 2021 26;5(2):487-495. PubMed PMID: 33496742
Hisada Y, Grover SP, Maqsood A, Houston R, Ay C, Noubouossie DF, Cooley BC, Wallén H, Key NS, Thålin C, Farkas ÁZ, Farkas VJ, Tenekedjiev K, Kolev K, Mackman N. Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors. Haematologica. 2020 105(1):218-225. PubMed PMID: 31048354
Hisada Y, Ay C, Auriemma AC, Cooley BC, Mackman N. Human pancreatic tumors grown in mice release tissue factor-positive microvesicles that increase venous clot size. J Thromb Haemost. 2017 15(11):2208-2217. PubMed PMID: 28834179.
My full publication list is here.
