The Frank Conlon group is utilizing new model systems, such as the frog Xenopus, to study the genetic causes of congenital heart disease, using gene editing tools coupled with the molecular, biochemical and imaging advantages these animals provide. Here we show an ultrasound image from a transverse cross-section through the chest region of a Xenopus froglet (approximately 1 cm long, above) with the Doppler imaging (below) to demonstrate blood flow through the heart ventricle.