Department of Genetics Publications February 13th – 26th, 2022

Department of Genetics faculty, postdocs, students and collaborators published 11 papers during February 13^th – 26^th, 2022.

 

A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics. 

Burclaff J, Bliton RJ, Breau KA, Ok MT, Gomez-Martinez I, Ranek JS, Bhatt AP, Purvis JE, Woosley JT, Magness ST.

Cell Mol Gastroenterol Hepatol. 2022 Feb 14:S2352-345X(22)00034-0. doi: 10.1016/j.jcmgh.2022.02.007. Online ahead of print.

PMID: 35176508

 

Subcutaneous adipose tissue splice quantitative trait loci reveal differences in isoform usage associated with cardiometabolic traits. 

Brotman SM, Raulerson CK, Vadlamudi S, Currin KW, Shen Q, Parsons VA, Iyengar AK, Roman TS, Furey TS, Kuusisto J, Collins FS, Boehnke M, Laakso M, Pajukanta P, Mohlke KL.

Am J Hum Genet. 2022 Jan 6;109(1):66-80. doi: 10.1016/j.ajhg.2021.11.019.

PMID: 34995504

 

A Conversation with Dr. Jenny Ting. 

Ting J.

J Interferon Cytokine Res. 2021 Oct;41(10):363-364. doi: 10.1089/jir.2021.29028.exp.

PMID: 34672800 No abstract available.

 

Quantitative profiling of adaptation to cyclin E overproduction. 

Limas JC, Littlejohn AN, House AM, Kedziora KM, Mouery BL, Ma B, Fleifel D, Walens A, Aleman MM, Dominguez D, Cook JG.

Life Sci Alliance. 2022 Feb 16;5(5):e202201378. doi: 10.26508/lsa.202201378. Print 2022 May.

PMID: 35173014

 

High Dimensional Change Point Inference: Recent Developments and Extensions. 

Liu B, Zhang X, Liu Y.

J Multivar Anal. 2022 Mar;188:104833. doi: 10.1016/j.jmva.2021.104833. Epub 2021 Sep 22.

PMID: 35177873

 

How can prenatal exome sequencing inform future pregnancies? 

Talati AN, Gilmore KL, Hardisty E, Vora NL.

Am J Obstet Gynecol. 2022 Feb 12:S0002-9378(22)00107-7. doi: 10.1016/j.ajog.2022.02.008. Online ahead of print.

PMID: 35167813 No abstract available.

 

Single-cell analysis reveals unexpected cellular changes and transposon expression signatures in the colonic epithelium of treatment-naïve adult Crohn’s disease patients. 

Kanke M, Kennedy Ng MM, Connelly S, Singh M, Schaner M, Shanahan MT, Wolber EA, Beasley C, Lian G, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Kapadia M, Guillem JG, Feschotte C, Furey TS, Sheikh SZ, Sethupathy P.

Cell Mol Gastroenterol Hepatol. 2022 Feb 11:S2352-345X(22)00032-7. doi: 10.1016/j.jcmgh.2022.02.005. Online ahead of print.

PMID: 35158099

 

The feasibility and potential of pharmacogenetics to reduce adverse drug events in nursing home residents. 

Kistler CE, Austin CA, Liu JJ, Cauble M, Wise A, Patel SM, Ward K, Wiltshire T, Zou F, Szeto AH, Crona DJ.

J Am Geriatr Soc. 2022 Feb 14. doi: 10.1111/jgs.17679. Online ahead of print.

PMID: 35157308 No abstract available.

 

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. 

Wang J, Yu X, Gong W, Liu X, Park KS, Ma A, Tsai YH, Shen Y, Onikubo T, Pi WC, Allison DF, Liu J, Chen WY, Cai L, Roeder RG, Jin J, Wang GG.

Nat Cell Biol. 2022 Feb 24. doi: 10.1038/s41556-022-00850-x. Online ahead of print.

PMID: 35210568

 

Rare coding variants in RCN3 are associated with blood pressure. 

He KY, Kelly TN, Wang H, Liang J, Zhu L, Cade BE, Assimes TL, Becker LC, Beitelshees AL, Bielak LF, Bress AP, Brody JA, Chang YC, Chang YC, de Vries PS, Duggirala R, Fox ER, Franceschini N, Furniss AL, Gao Y, Guo X, Haessler J, Hung YJ, Hwang SJ, Irvin MR, Kalyani RR, Liu CT, Liu C, Martin LW, Montasser ME, Muntner PM, Mwasongwe S, Naseri T, Palmas W, Reupena MS, Rice KM, Sheu WH, Shimbo D, Smith JA, Snively BM, Yanek LR, Zhao W, Blangero J, Boerwinkle E, Chen YI, Correa A, Cupples LA, Curran JE, Fornage M, He J, Hou L, Kaplan RC, Kardia SLR, Kenny EE, Kooperberg C, Lloyd-Jones D, Loos RJF, Mathias RA, McGarvey ST, Mitchell BD, North KE, Peyser PA, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Rotter JI, Taylor KD, Tracy R, Vasan RS; Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Morrison AC, Levy D, Chakravarti A, Arnett DK, Zhu X.

BMC Genomics. 2022 Feb 19;23(1):148. doi: 10.1186/s12864-022-08356-4.

PMID: 35183128 Free PMC article.

 

Joint gene network construction by single-cell RNA sequencing data. 

Dong M, He Y, Jiang Y, Zou F.

Biometrics. 2022 Feb 19. doi: 10.1111/biom.13645. Online ahead of print.

PMID: 35184277