Department of Genetics faculty, postdocs, students and collaborators published six papers during July 28 – August 10, 2019.

 

Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y.
Nat Genet. 2019 Aug;51(8):1252-1262. doi: 10.1038/s41588-019-0472-1. Epub 2019 Jul 31.
PMID: 31367015

 

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
Evangelou E, Gao H, Chu C, Ntritsos G, Blakeley P, Butts AR, Pazoki R, Suzuki H, Koskeridis F, Yiorkas AM, Karaman I, Elliott J, Luo Q, Aeschbacher S, Bartz TM, Baumeister SE, Braund PS, Brown MR, Brody JA, Clarke TK, Dimou N, Faul JD, Homuth G, Jackson AU, Kentistou KA, Joshi PK, Lemaitre RN, Lind PA, Lyytikäinen LP, Mangino M, Milaneschi Y, Nelson CP, Nolte IM, Perälä MM, Polasek O, Porteous D, Ratliff SM, Smith JA, Stančáková A, Teumer A, Tuominen S, Thériault S, Vangipurapu J, Whitfield JB, Wood A, Yao J, Yu B, Zhao W, Arking DE, Auvinen J, Liu C, Männikkö M, Risch L, Rotter JI, Snieder H, Veijola J, Blakemore AI, Boehnke M, Campbell H, Conen D, Eriksson JG, Grabe HJ, Guo X, van der Harst P, Hartman CA, Hayward C, Heath AC, Jarvelin MR, Kähönen M, Kardia SLR, Kühne M, Kuusisto J, Laakso M, Lahti J, Lehtimäki T, McIntosh AM, Mohlke KL, Morrison AC, Martin NG, Oldehinkel AJ, Penninx BWJH, Psaty BM, Raitakari OT, Rudan I, Samani NJ, Scott LJ, Spector TD, Verweij N, Weir DR, Wilson JF, Levy D, Tzoulaki I, Bell JD, Matthews PM, Rothenfluh A, Desrivières S, Schumann G, Elliott P.
Nat Hum Behav. 2019 Jul 29. doi: 10.1038/s41562-019-0653-z. [Epub ahead of print]
PMID: 31358974

 

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk.
Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY.
Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z.
PMID: 31346172

 

Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements.
Elango R, Osia B, Harcy V, Malc E, Mieczkowski PA, Roberts SA, Malkova A.
Nucleic Acids Res. 2019 Aug 8. pii: gkz651. doi: 10.1093/nar/gkz651. [Epub ahead of print]
PMID: 31392335

 

Nonparametric expression analysis using inferential replicate counts.
Zhu A, Srivastava A, Ibrahim JG, Patro R, Love MI.
Nucleic Acids Res. 2019 Aug 2. pii: gkz622. doi: 10.1093/nar/gkz622. [Epub ahead of print]
PMID: 31372651

 

Centromere-Proximal Meiotic Crossovers in <i>Drosophila melanogaster</i> Are Suppressed by Both Highly-Repetitive Heterochromatin and Proximity to the Centromere.
Hartmann M, Umbanhowar J, Sekelsky J.
Genetics. 2019 Jul 25. pii: genetics.302509.2019. doi: 10.1534/genetics.119.302509. [Epub ahead of print]
PMID: 31345993