Department of Genetics faculty, postdocs, students and collaborators published eleven papers during May 17-30, 2020.

 

Test-statistic inflation in methylome-wide association studies.
Guintivano J, Shabalin AA, Chan RF, Rubinow DR, Sullivan PF, Meltzer-Brody S, Aberg KA, van den Oord EJCG.
Epigenetics. 2020 May 19:1-4. doi: 10.1080/15592294.2020.1758382. [Epub ahead of print]
PMID: 32425094

 

Parental Views on Newborn Next Generation Sequencing: Implications for Decision Support.
Moultrie RR, Paquin R, Rini C, Roche MI, Berg JS, Powell CM, Lewis MA.
Matern Child Health J. 2020 May 18. doi: 10.1007/s10995-020-02953-z. [Epub ahead of print]
PMID: 32424581

 

Crohn’s Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria.
Shahir NM, Wang JR, Wolber EA, Schaner MS, Frank DN, Ir D, Robertson CE, Chaumont N, Sadiq TS, Koruda MJ, Rahbar R, Nix BD, Newberry RD, Sartor RB, Sheikh SZ, Furey TS.
Inflamm Bowel Dis. 2020 May 29. pii: izaa103. doi: 10.1093/ibd/izaa103. [Epub ahead of print]
PMID: 32469069

 

Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus.
Das A, Barrientos R, Shiota T, Madigan V, Misumi I, McKnight KL, Sun L, Li Z, Meganck RM, Li Y, Kaluzna E, Asokan A, Whitmire JK, Kapustina M, Zhang Q, Lemon SM.
Nat Microbiol. 2020 May 25. doi: 10.1038/s41564-020-0727-8. [Epub ahead of print]
PMID: 32451473

 

Genetic stratification of depression in UK Biobank.
Howard DM, Folkersen L, Coleman JRI, Adams MJ, Glanville K, Werge T, Hagenaars SP, Han B, Porteous D, Campbell A, Clarke TK, Breen G, Sullivan PF, Wray NR, Lewis CM, McIntosh AM.
Transl Psychiatry. 2020 May 24;10(1):163. doi: 10.1038/s41398-020-0848-0.
PMID: 32448866

 

USP37 promotes deubiquitination of HIF2α in kidney cancer.
Hong K, Hu L, Liu X, Simon JM, Ptacek TS, Zheng X, Liao C, Baldwin AS, Zhang Q.
Proc Natl Acad Sci U S A. 2020 May 27. pii: 202002567. doi: 10.1073/pnas.2002567117. [Epub ahead of print]
PMID: 32461361

 

ANCA autoantigen gene expression highlights neutrophil heterogeneity where expression in normal-density neutrophils correlates with ANCA-induced activation.
Jones BE, Herrera CA, Agosto-Burgos C, Starmer J, Bass WA, Poulton CJ, Blazek L, Henderson CD, Hu Y, Hogan SL, Hu P, Xiao H, Wu EY, Chen DP, Jennette JC, Free ME, Falk RJ, Ciavatta DJ.
Kidney Int. 2020 May 21. pii: S0085-2538(20)30538-X. doi: 10.1016/j.kint.2020.04.037. [Epub ahead of print]
PMID: 32446935

 

SCOPE: A Normalization and Copy-Number Estimation Method for Single-Cell DNA Sequencing.
Wang R, Lin DY, Jiang Y.
Cell Syst. 2020 May 20;10(5):445-452.e6. doi: 10.1016/j.cels.2020.03.005.
PMID: 32437686

 

The effect of LRRK2 loss-of-function variants in humans.
Whiffin N, Armean IM, Kleinman A, Marshall JL, Minikel EV, Goodrich JK, Quaife NM, Cole JB, Wang Q, Karczewski KJ, Cummings BB, Francioli L, Laricchia K, Guan A, Alipanahi B, Morrison P, Baptista MAS, Merchant KM; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Ware JS, Havulinna AS, Iliadou B, Lee JJ, Nadkarni GN, Whiteman C; 23andMe Research Team, Daly M, Esko T, Hultman C, Loos RJF, Milani L, Palotie A, Pato C, Pato M, Saleheen D, Sullivan PF, Alföldi J, Cannon P, MacArthur DG.
Nat Med. 2020 May 27. doi: 10.1038/s41591-020-0893-5. [Epub ahead of print]
PMID: 32461697

 

Ensemble estimation and variable selection with semiparametric regression models.
Shin S, Liu Y, Cole SR, Fine JP.
Biometrika. 2020 Jun;107(2):433-448. doi: 10.1093/biomet/asaa012. Epub 2020 Apr 15.
PMID: 32454529

 

A murine model of increased coronary sinus pressure induces myocardial edema with cardiac lymphatic dilation and fibrosis.
Nielsen NR, Rangarajan KV, Mao L, Rockman HA, Caron KM.
Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H895-H907. doi: 10.1152/ajpheart.00436.2019. Epub 2020 Mar 6.
PMID: 32142379