Department of Genetics faculty, postdocs, students and collaborators published ten papers during Nov. 3-16, 2019.

 

Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution.
Wu Y, Broadaway KA, Raulerson CK, Scott LJ, Pan C, Ko A, He A, Tilford C, Fuchsberger C, Locke AE, Stringham HM, Jackson AU, Narisu N, Kuusisto J, Pajukanta P, Collins FS, Boehnke M, Laakso M, Lusis AJ, Civelek M, Mohlke KL.
Hum Mol Genet. 2019 Nov 6. pii: ddz263. doi: 10.1093/hmg/ddz263. [Epub ahead of print]
PMID: 31691812

 

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits.
Zhao B, Luo T, Li T, Li Y, Zhang J, Shan Y, Wang X, Yang L, Zhou F, Zhu Z; Alzheimer’s Disease Neuroimaging Initiative; Pediatric Imaging, Neurocognition and Genetics, Zhu H.
Nat Genet. 2019 Nov 1. doi: 10.1038/s41588-019-0516-6. [Epub ahead of print]
PMID: 31676860

 

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.
Zurlo G, Liu X, Takada M, Fan C, Simon JM, Ptacek TS, Rodriguez J, von Kriegsheim A, Liu J, Locasale JW, Robinson A, Zhang J, Holler JM, Kim B, Zikánová M, Bierau J, Xie L, Chen X, Li M, Perou CM, Zhang Q.
Nat Commun. 2019 Nov 15;10(1):5177. doi: 10.1038/s41467-019-13168-4.
PMID: 31729379

 

Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.
Forstner AJ, Awasthi S, Wolf C, Maron E, Erhardt A, Czamara D, Eriksson E, Lavebratt C, Allgulander C, Friedrich N, Becker J, Hecker J, Rambau S, Conrad R, Geiser F, McMahon FJ, Moebus S, Hess T, Buerfent BC, Hoffmann P, Herms S, Heilmann-Heimbach S, Kockum I, Olsson T, Alfredsson L, Weber H, Alpers GW, Arolt V, Fehm L, Fydrich T, Gerlach AL, Hamm A, Kircher T, Pané-Farré CA, Pauli P, Rief W, Ströhle A, Plag J, Lang T, Wittchen HU, Mattheisen M, Meier S, Metspalu A, Domschke K, Reif A, Hovatta I, Lindefors N, Andersson E, Schalling M, Mbarek H, Milaneschi Y, de Geus EJC, Boomsma DI, Penninx BWJH, Thorgeirsson TE, Steinberg S, Stefansson K, Stefansson H, Müller-Myhsok B, Hansen TF, Børglum AD, Werge T, Mortensen PB, Nordentoft M, Hougaard DM, Hultman CM, Sullivan PF, Nöthen MM, Woldbye DPD, Mors O, Binder EB, Rück C, Ripke S, Deckert J, Schumacher J.
Mol Psychiatry. 2019 Nov 11. doi: 10.1038/s41380-019-0590-2. [Epub ahead of print]
PMID: 31712720

 

Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders.
Bauer AE, Liu X, Byrne EM, Sullivan PF, Wray NR, Agerbo E, Nyegaard M, Grove J, Musliner KL, Ingstrup KG, Johannsen BMW, Mægbæk ML, Wang Y, Nordentoft M, Mors O, Børglum AD, Werge T, Hougaard DM, Mortensen PB, Munk-Olsen T, Meltzer-Brody S.
Transl Psychiatry. 2019 Nov 11;9(1):288. doi: 10.1038/s41398-019-0629-9.
PMID: 3171265

 

Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery.
Weaver KN, Kochar B, Hansen JJ, Isaacs KL, Jain A, Sheikh SZ, Fichera A, Chaumont N, Sadiq T, Koruda M, Long MD, Herfarth HH, Barnes EL.
Crohns Colitis 360. 2019 Oct;1(3):otz029. doi: 10.1093/crocol/otz029. Epub 2019 Sep 26.
PMID: 31667470

 

A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers.
Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT.
Nat Commun. 2019 Oct 28;10(1):4907. doi: 10.1038/s41467-019-12812-3.
PMID: 31659164

 

Long-Term Complications of Ebola Virus Disease: Prevalence and Predictors of Major Symptoms and the Role of Inflammation.
Tozay S, Fischer WA, Wohl DA, Kilpatrick K, Zou F, Reeves E, Pewu K, DeMarco J, Loftis AJ, King K, Grant D, Schieffelin J, Gorvego G, Johnson H, Conneh T, Williams G, Nelson JAE, Hoover D, McMillian D, Merenbloom C, Hawks D, Dube K, Brown J.
Clin Infect Dis. 2019 Nov 6. pii: ciz1062. doi: 10.1093/cid/ciz1062. [Epub ahead of print]
PMID: 31693114

 

Modeling tumor evolutionary dynamics to predict clinical outcomes for patients with metastatic colorectal cancer: a retrospective analysis.
Zhou J, Liu Y, Zhang Y, Li Q, Cao Y.
Cancer Res. 2019 Nov 1. pii: canres.1940.2019. doi: 10.1158/0008-5472.CAN-19-1940. [Epub ahead of print]
PMID: 31676575

 

RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis.
Mackie DI, Nielsen NR, Harris M, Singh S, Davis RB, Dy D, Ladds G, Caron KM.
Proc Natl Acad Sci U S A. 2019 Nov 11. pii: 201905561. doi: 10.1073/pnas.1905561116. [Epub ahead of print]
PMID: 31712427