Patrick Sullivan is a Distinguished Professor in the Department of Genetics and Psychiatry at the University of North Carolina at Chapel Hill and also Professor at the Karolinska Institute in Stockholm, Sweden. He is a founder and the lead principal investigator of the Psychiatric Genomics Consortium as well as a Swedish national complex trait consortium and its extension to Denmark and Norway (focusing on psychiatric disorders). His labs investigate the molecular genetics of schizophrenia, major depressive disorder (including post-partum depression), and eating disorders. He has an outstanding track record of training post-docs and in advancing them to faculty positions and independent R01 funding. Dr Sullivan has 433 total publications including 375 papers (peer-reviewed: published, in press, or submitted) and 58 other contributions (reviews, editorials, comments, invited manuscripts, or chapters). Google Scholar h-index 114. In the past 10 years, essentially all of his empirical papers have had trainees as co-authors.
Research Interests
Key words: complex traits in humans, psychiatric genetics, pharmacogenetics, schizophrenia, major depression, eating disorders
The Sullivan lab aims to understand the genetic and epidemiological basis of a number of important public-health problems. These disorders are etiologically heterogeneous and exhibit complex patterns of inheritance. Developing an understanding of these disorders requires the integration of findings from multiple investigative approaches such as epidemiology, linkage analysis, and association studies. The lab applies these methods to several research areas:
Schizophrenia
This is a chronic and debilitating mental disorder that affects approximately 1% of the human population. Although it is clear that genetics plays a role in schizophrenia, specific genes that have a causal role in the disease have yet to be identified. The Sullivan lab is conducting a series of studies to elucidate its etiology. In addition, pharmacogenetic studies are underway to determine the mechanism of action of antipsychotic drugs that are currently used to treat some of the symptoms of schizophrenia.
Mentor Training:
Publications
Patrick Sullivan in UNC Genetics News

May 22, 2023
Department of Genetics Publications for May 7th – 20th, 2023
Department of Genetics faculty, postdocs, students and collaborators published 9 papers during May 7th – 20th, 2023.

May 7, 2023
Department of Genetics Publications for April 23rd – May 6th, 2023
Department of Genetics faculty, postdocs, students and collaborators published 11 papers during April 23rd – May 6th, 2023.

April 27, 2023
Mammalian Evolution Provides Hints for Understanding the Origins of Human Disease
UNC School of Medicine’s Patrick Sullivan, MD, FRANZCP, and a team of scientists in the Psychiatric Genetic Consortium have created a new manual researchers can use to learn more about the origins of human diseases with high genetic risk.

March 27, 2023
Department of Genetics Publications for March 12th – 25th, 2023
Department of Genetics faculty, postdocs, students and collaborators published 8 papers during March 12th – 25th, 2023. Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Liu D, Meyer D, Fennessy B, Feng C, Cheng E, Johnson JS, Park YJ, Rieder MK, Ascolillo S, de Pins A, Dobbyn A, Lebovitch D, Moya …

January 30, 2023
Department of Genetics Publications for January 15th – 28th, 2023
Department of Genetics faculty, postdocs, students and collaborators published 16 papers during January 15th – 28th, 2023.

December 18, 2022
Department of Genetics Publications for December 4th – 17th, 2022
Department of Genetics faculty, postdocs, students and collaborators published 8 papers during December 4th – 17th, 2022.

December 5, 2022
Department of Genetics Publications for November 20th – December 3rd, 2022
Department of Genetics faculty, postdocs, students and collaborators published 12 papers during November 20th – December 3rd, 2022.

December 1, 2022
Scientists Link Rare Genetics Phenomenon to Neuron Function, Schizophrenia
Led by Jin Szatkiewicz, PhD, UNC School of Medicine researchers and University of Toronto colleagues found that a rare form of a common genetic variant called tandem repeats is strongly associated with the development of schizophrenia.

November 20, 2022
Department of Genetics Publications for November 6th – 19th, 2022
Department of Genetics faculty, postdocs, students and collaborators published 11 papers during November 6th – 19th, 2022.

October 24, 2022
Department of Genetics Publications for October 9th – 22nd, 2022
Department of Genetics faculty, postdocs, students and collaborators published 10 papers during October 9th – 22nd, 2022.