Research Interests
Keywords: Epigenetics, Chromatin remodeling, Development, Gametogenesis, Meiosis.
Successful gametogenesis is the key to the perpetuation of a species. Germ cells are unique in nature and undergo both mitosis and meiosis successively to produce mature gametes. During meiotic prophase, germ cells undergo genetic recombination by initiation and repair of DNA double strand breaks to introduce genetic diversity, and extensive changes in transcription as well to promote transcription of meiotic genes. These processes involve several checkpoints to ensure the final gametes are free of aneuploidy, mutations, and overall genomic instability. Chromatin modifiers and remodelers play key role in these processes.
We are currently interested about the chromatin remodelers in male germ cell development. We use a multiomic approach to determine genomewide transcription, chromatin regulators and transcription factor binding, chromatin accessibility in combination to proteomic analysis to determine how the interplay of chromatin modifiers, DNA repair factors and chromatin state facilitate germ cell development. Our studies indicate that a chromatin remodeler INO80 is necessary for DNA double strand break repair and silencing the somatic gene expression in spermatocytes to facilitate meiotic gene expression. INO80 also interacts with other meiotic factors, and we are currently exploring the role of INO80 in meiotic processes in different stages during development.
Mentor Training
- REI Racial Equity Workshop Phase 1
Prabuddha Chakraborty in UNC Genetics News
June 6, 2022
Department of Genetics Publications May 22nd – June 4th, 2022
Department of Genetics faculty, postdocs, students and collaborators published 10 papers during May 22nd – June 4th, 2022.
January 17, 2022
Department of Genetics Publications January 2nd – 15th 2022
Department of Genetics faculty, postdocs, students and collaborators published eleven papers during January 2nd – 15th, 2022.
June 4, 2021
Department of Genetics Welcomes New Faculty
Four new Assistant Professors have recently been appointed in the Department of Genetics.
November 2, 2020
Department of Genetics Publications for October 11-31, 2020
Department of Genetics faculty, postdocs, students and collaborators published 18 papers during October 11-31, 2020. Survival, Pathologic Response, and Genomics in CALGB 40601 (Alliance), a Neoadjuvant Phase III Trial of Paclitaxel-Trastuzumab With or Without Lapatinib in HER2-Positive Breast Cancer. Fernandez-Martinez A, Krop IE, Hillman DW, Polley MY, Parker JS, Huebner L, Hoadley KA, …
March 27, 2019
Department of Genetics Publications for March 10-23, 2019
Department of Genetics faculty, postdocs, students and collaborators published fifteen papers during March 10-23, 2019.
