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Department of Genetics faculty, postdocs, students and collaborators published fifteen papers during March 10-23, 2019.

Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes.
Fang Z, Weng C, Li H, Tao R, Mai W, Liu X, Lu L, Lai S, Duan Q, Alvarez C, Arvan P, Wynshaw-Boris A, Li Y, Pei Y, Jin F, Li Y.
Cell Rep. 2019 Mar 12;26(11):3132-3144.e7. doi: 10.1016/j.celrep.2019.02.043.
PMID: 30865899


Mapping causal pathways from genetics to neuropsychiatric disorders using genome-wide imaging genetics: current status and future directions.
Le BD, Stein JL.
Psychiatry Clin Neurosci. 2019 Mar 13. doi: 10.1111/pcn.12839. [Epub ahead of print]
PMID: 30864184


vqtl: An R Package for Mean-Variance QTL Mapping.
Corty RW, Valdar W.
G3 (Bethesda). 2018 Dec 10;8(12):3757-3766. doi: 10.1534/g3.118.200642.
PMID: 30389795


QTL Mapping on a Background of Variance Heterogeneity.
Corty RW, Valdar W.
G3 (Bethesda). 2018 Dec 10;8(12):3767-3782. doi: 10.1534/g3.118.200790.
PMID: 30389794


Mean-Variance QTL Mapping Identifies Novel QTL for Circadian Activity and Exploratory Behavior in Mice.
Corty RW, Kumar V, Tarantino LM, Takahashi JS, Valdar W.
G3 (Bethesda). 2018 Dec 10;8(12):3783-3790. doi: 10.1534/g3.118.200194.
PMID: 30389793


The three-dimensional landscape of the genome in human brain tissue unveils regulatory mechanisms leading to schizophrenia risk.
Mah W, Won H.
Schizophr Res. 2019 Mar 17. pii: S0920-9964(19)30089-1. doi: 10.1016/j.schres.2019.03.007. [Epub ahead of print] Review.
PMID: 30894290


Evidence that the human cell cycle is a series of uncoupled, memoryless phases.
Chao HX, Fakhreddin RI, Shimerov HK, Kedziora KM, Kumar RJ, Perez J, Limas JC, Grant GD, Cook JG, Gupta GP, Purvis JE.
Mol Syst Biol. 2019 Mar 18;15(3):e8604. doi: 10.15252/msb.20188604.
PMID: 30886052


Reciprocal F1 Hybrids of Two Inbred Mouse Strains Reveal Parent-of-Origin and Perinatal Diet Effects on Behavior and Expression.
Oreper D, Schoenrock SA, McMullan R, Ervin R, Farrington J Miller DR, de Villena FP, Valdar W, Tarantino LM,.
G3 (Bethesda). 2018 Nov 6;8(11):3447-3468. doi: 10.1534/g3.118.200135.
PMID: 30171036


High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq.
Simon JM, Paranjape SR, Wolter JM, Salazar G, Zylka MJ.
Sci Rep. 2019 Mar 14;9(1):4529. doi: 10.1038/s41598-019-39016-5.
PMID: 30872602


Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β-induced Serpine1.
McCann JV, Xiao L, Kim DJ, Khan OF, Kowalski PS, Anderson DG, Pecot CV, Azam SH, Parker JS, Tsai YS, Wolberg AS, Turner SD, Tatsumi K, Mackman N, Dudley AC.
J Clin Invest. 2019 Mar 11;130. pii: 123106. doi: 10.1172/JCI123106. eCollection 2019 Mar 11.
PMID: 30855280


RNA-Sequencing of Umbilical Cord Blood to Investigate Spontaneous Preterm Birth: A Pilot Study.
Vora NL, Parker JS, Mieckowski PA, Smeester L, Fry RC, Boggess KA.
AJP Rep. 2019 Jan;9(1):e60-e66. doi: 10.1055/s-0039-1678717. Epub 2019 Mar 7.
PMID: 30854245


A Case Study of Genomic Instability in an Industrial Strain of <i>Saccharomyces cerevisiae</i>.
Rodrigues-Prause A, Sampaio NMV, Gurol TM, Aguirre GM, Sedam HNC, Chapman MJ, Malc EP, Ajith VP, Chakraborty P, Tizei PA, Pereira GAG, Mieczkowski PA, Nishant KT, Argueso JL.
G3 (Bethesda). 2018 Nov 6;8(11):3703-3713. doi: 10.1534/g3.118.200446.
PMID: 30254181


Centrosome Loss Triggers a Transcriptional Program To Counter Apoptosis-Induced Oxidative Stress.
Poulton JS, McKay DJ, Peifer M.
Genetics. 2019 Mar 13. pii: genetics.302051.2019. doi: 10.1534/genetics.119.302051. [Epub ahead of print]
PMID: 30867197


Next-Generation Sequencing (NGS) Methods Show Superior or Equivalent Performance to Non-NGS Methods on BRAF, EGFR, and KRAS Proficiency Testing Samples.
Surrey LF, Oakley FD, Merker JD, Long TA, Vasalos P, Moncur JT, Kim AS.
Arch Pathol Lab Med. 2019 Mar 13. doi: 10.5858/arpa.2018-0394-CP. [Epub ahead of print]
PMID: 30865489


Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation.
Leatham-Jensen M, Uyehara CM, Strahl BD, Matera AG, Duronio RJ, McKay DJ.
PLoS Genet. 2019 Jan 30;15(1):e1007932. doi: 10.1371/journal.pgen.1007932. eCollection 2019 Jan.
PMID: 30699116