Key words: gene-environment interactions, systems genetics, asthma, environmentally-induced lung disease
My long-standing research interest has been in gene-environment interactions (GxE) with environmental health hazards. My motivation stems from the desire to understand inter-individual variation in response to exposures associated with disease, and my training in both toxicology and genetics allows me to marry these two disciplines. The central focus of my lab is on the identification of GxE with air pollutants and allergens that affect the development of common airway diseases like asthma and COPD, with the mindset that identifying GxE provides an important means to gain information about disease susceptibility and mechanisms underlying the association between exposures and disease.
Robust detection of GxE requires maximizing information about both genetic variation (G) and environmental exposure (E), which is very challenging in human studies. Thus, we leverage model systems, mice in particular, in which we control both G and E. On the genetics side, we have worked heavily with the Collaborative Cross (CC), a mouse genetics reference population that features abundant genetic variation in format of inbred lines. On the exposure side, we have established state-of-the-art inhalation exposure systems to deliver precise air pollutant exposures to rodents; and we aim to expand our capacity to model exposures to additional air pollutants and other common respiratory exposures associated with respiratory disease.
Ultimately, of course, we seek to translate our findings from model systems to humans. To that end, we collaborate with investigators at the UNC Center for Environmental Medicine, Asthma and Lung Biology, the UNC Center for Environmental Health and Susceptibility, and the UNC Marsico Lung Institute, to enable such cross-species comparisons in the context of clinical and/or epidemiologic data. Thus, in total, our work is multidisciplinary and utilizes approaches from genetics, toxicology, and epidemiology. To learn about current projects in the lab, please see our website.
- Bias 101
- Culturally Aware Mentoring
- Faculty Mentoring Workshop for Biomedical Researchers
Training Program Affiliations:
- Bioinformatics and Computational Biology
- Genetics and Molecular Biology
Samir Kelada in UNC Genetics News
April 21, 2022
Kelada and Mohlke awarded 5-year R01 from NIEHS
Dr. Samir Kelada (Associate Professor, Genetics) and Dr. Karen Mohlke (Professor, Genetics) were awarded a 5 year R01 from the National Institute of Environmental Health Sciences (NIEHS) titled “Regulatory Genomics of Ozone Air Pollution Response in Vitro and In Vivo”.
April 11, 2022
Department of Genetics Publications March 27th – April 9th, 2022
Department of Genetics faculty, postdocs, students and collaborators published 17 papers during March 27th – April 9th, 2022.
November 15, 2021
Department of Genetics Publications October 31st – November 13th 2021
Department of Genetics faculty, postdocs, students and collaborators published 12 papers during October 31st – November 13th 2021. A multi-omic single-cell landscape of human gynecologic malignancies. Regner MJ, Wisniewska K, Garcia-Recio S, Thennavan A, Mendez-Giraldez R, Malladi VS, Hawkins G, Parker JS, Perou CM, Bae-Jump VL, Franco HL. Mol Cell. 2021 Nov 1:S1097-2765(21)00842-X. doi: …
October 4, 2021
Department of Genetics Publications September 19th – October 2nd 2021
Department of Genetics faculty, postdocs, students and collaborators published 14 papers during September 19th – October 2nd 2021.
August 10, 2021
Dr. Samir Kelada Awarded New R21 from NIEHS
Dr. Samir Kelada (Associate Professor, Department of Genetics) is the PI on a new R21 grant from the National Institute of Environmental Health Sciences (NIEHS) titled “Gene-Environment Interactions with Ozone and Non-atopic Asthma”.
July 24, 2021
Department of Genetics Publications for July 11th – July 24th, 2021
Department of Genetics faculty, postdocs, students and collaborators published 12 papers during July 11th - July 24th, 2021.
May 19, 2021
Samir Kelada, PhD Awarded R21 Grant from NIAID
Dr. Samir Kelada (Associate Professor, Department of Genetics) has been awarded a new R21 grant from the National Institutes of Allergy and Infectious Diseases (NIAID) for his project titled “A New Mouse Model of Severe Asthma”.
February 16, 2021
GENETICS article “Inferring the Allelic Series at QTL in Multiparental Populations” has been chosen for the 2020 GSA Spotlight
The paper, published by Drs. Wesley Krouse, Samir Kelada and William Valdar in GENETICS December 2020, was selected for the 2020 Spotlight collection of research and scholarship excellence published in the GSA journals.
December 18, 2020
Samir Kelada, PhD Receives Bridge Funding from SOM Dean’s Office
Dr. Samir Kelada (Associate Professor) was awarded bridge funding from the UNC SOM Dean’s Office for his project “Genome-wide analyses of gene-environment interactions with the air pollutant ozone”.
November 16, 2020
GENETICS Editors Highlight Paper by Crouse, Kelada and Valdar in December 2020 Issue
Drs. Wesley Crouse, Samir Kelada and Will Valdar (UNC Department of Genetics) published the manuscript “Inferring the Allelic Series at QTL in Multiparental Populations” in the October 20, 2020 edition of the journal GENETICS. This paper will be featured as an issue highlight in the December 2020 edition of the journal. The article follows: Multiparent …