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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 14 papers during August 14th – 27th, 2022.


Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy. 

Kyere FA, Curtin I, Krupa O, McCormick CM, Dere M, Khan S, Kim M, Wang TW, He Q, Wu G, Shih YI, Stein JL.

J Vis Exp. 2022 Aug 1;(186). doi: 10.3791/64096.

PMID: 35969091


Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor-Positive Breast Cancer. 

Xia Y, He X, Renshaw L, Martinez-Perez C, Kay C, Gray M, Meehan J, Parker JS, Perou CM, Carey LA, Dixon JM, Turnbull A.

Clin Cancer Res. 2022 Aug 15;28(16):3618-3629. doi: 10.1158/1078-0432.CCR-21-3189.

PMID: 35653148


Epigenome-wide association study analysis of calorie restriction in humans, CALERIE TM Trial analysis. 

Ramaker ME, Corcoran DL, Apsley AT, Kobor MS, Kraus VB, Kraus WE, Lin DTS, Orenduff MC, Pieper CF, Waziry R, Huffman KM, Belsky DW.

J Gerontol A Biol Sci Med Sci. 2022 Aug 15:glac168. doi: 10.1093/gerona/glac168. Online ahead of print.

PMID: 35965483


SARS-CoV-2 Seroprevalence: Demographic and Behavioral Factors Associated With Seropositivity Among College Students in a University Setting. 

Diepstra K, Bullington BW, Premkumar L, Shook-Sa BE, Jones C, Pettifor A.

J Adolesc Health. 2022 Jul 4:S1054-139X(22)00510-9. doi: 10.1016/j.jadohealth.2022.06.015. Online ahead of print.

PMID: 35985917


History of the Relationship between Smoking and Bladder Cancer: A Public Health Perspective. 

Weiss K, Matulewicz RS, Morton E, Shoenbill K, Milowsky MI, Rose TL, Kim WY, Goldstein A, Bjurlin MA.

Urology. 2022 Aug 14:S0090-4295(22)00705-1. doi: 10.1016/j.urology.2022.08.007. Online ahead of print.

PMID: 35977631 No abstract available.


Low-Intensity Focused Ultrasound Produces Immune Response in Pancreatic Cancer. 

Joiner JB, Kren NP, Durham PG, McRee AJ, Dayton PA, Pylayeva-Gupta Y.

Ultrasound Med Biol. 2022 Aug 24:S0301-5629(22)00469-0. doi: 10.1016/j.ultrasmedbio.2022.06.017. Online ahead of print.

PMID: 36028460


Obesity reprograms the pulmonary polyunsaturated fatty acid-derived lipidome, transcriptome, and gene-oxylipin networks. 

Virk R, Buddenbaum N, Al-Shaer A, Armstrong M, Manke J, Reisdorph N, Sergin S, Fenton JI, Wallace ED, Ehrmann BM, Lovins HB, Gowdy KM, Smith MR, Smith GJ, Kelada SNP, Shaikh SR.

J Lipid Res. 2022 Aug 23:100267. doi: 10.1016/j.jlr.2022.100267. Online ahead of print.

PMID: 36028048


Clinical subtype, treatment response, and survival in De Novo and recurrent metastatic breast cancer. 

File DM, Pascual T, Deal AM, Wheless A, Perou CM, Claire Dees E, Carey LA.

Breast Cancer Res Treat. 2022 Aug 25. doi: 10.1007/s10549-022-06700-6. Online ahead of print.

PMID: 36008651


Inference of putative cell-type specific imprinted regulatory elements and genes during human neuronal differentiation. 

Liang D, Aygün N, Matoba N, Ideraabdullah FY, Love MI, Stein JL.

Hum Mol Genet. 2022 Aug 22:ddac207. doi: 10.1093/hmg/ddac207. Online ahead of print.

PMID: 35994039


TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner. 

Äijö T, Theofilatos D, Cheng M, Smith MD, Xiong Y, Baldwin AS, Tsagaratou A.

Front Immunol. 2022 Aug 5;13:940995. doi: 10.3389/fimmu.2022.940995. eCollection 2022.

PMID: 35990681 Free PMC article.


Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations. 

Elgart M, Lyons G, Romero-Brufau S, Kurniansyah N, Brody JA, Guo X, Lin HJ, Raffield L, Gao Y, Chen H, de Vries P, Lloyd-Jones DM, Lange LA, Peloso GM, Fornage M, Rotter JI, Rich SS, Morrison AC, Psaty BM, Levy D, Redline S; NHLBI’s Trans-Omics in Precision Medicine (TOPMed) Consortium, Sofer T.

Commun Biol. 2022 Aug 22;5(1):856. doi: 10.1038/s42003-022-03812-z.

PMID: 35995843 Free PMC article.


Prenatal Exome and Genome Sequencing for Fetal Structural Abnormalities. 

Vora NL, Norton ME.

Am J Obstet Gynecol. 2022 Aug 23:S0002-9378(22)00683-4. doi: 10.1016/j.ajog.2022.08.040. Online ahead of print.

PMID: 36027950 Review.


Intrathecal idursulfase-IT in patients with neuronopathic mucopolysaccharidosis II: Results from a phase 2/3 randomized study. 

Muenzer J, Burton BK, Harmatz P, Gutiérrez-Solana LG, Ruiz-Garcia M, Jones SA, Guffon N, Inbar-Feigenberg M, Bratkovic D, Hale M, Wu Y, Yee KS, Whiteman DAH, Alexanderian D; HGT-HIT-094 Study Group.

Mol Genet Metab. 2022 Aug 2;137(1-2):127-139. doi: 10.1016/j.ymgme.2022.07.017. Online ahead of print.

PMID: 36027721


Gestational diabetes mellitus placentas exhibit epimutations at placental development genes. 

Meyrueix LP, Gharaibeh R, Xue J, Brouwer C, Jones C, Adair L, Norris SA, Ideraabdullah F.

Epigenetics. 2022 Aug 21:1-21. doi: 10.1080/15592294.2022.2111751. Online ahead of print.

PMID: 35993304