Department of Genetics Publications October 31st – November 13th 2021

Department of Genetics faculty, postdocs, students and collaborators published 12 papers during October 31^st – November 13^th 2021.

 

A multi-omic single-cell landscape of human gynecologic malignancies. 

Regner MJ, Wisniewska K, Garcia-Recio S, Thennavan A, Mendez-Giraldez R, Malladi VS, Hawkins G, Parker JS, Perou CM, Bae-Jump VL, Franco HL.

Mol Cell. 2021 Nov 1:S1097-2765(21)00842-X. doi: 10.1016/j.molcel.2021.10.013. Online ahead of print.

PMID: 34739872

 

TP53 pathway function, estrogen receptor status, and breast cancer risk factors in the Carolina Breast Cancer Study. 

Hurson AN, Abubakar M, Hamilton AM, Conway K, Hoadley KA, Love MI, Olshan AF, Perou CM, Garcia-Closas M, Troester MA.

Cancer Epidemiol Biomarkers Prev. 2021 Nov 4:cebp.0661.2021. doi: 10.1158/1055-9965.EPI-21-0661. Online ahead of print.

PMID: 34737209

 

Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project. 

Hu Y, Haessler JW, Manansala R, Wiggins KL, Moscati A, Beiser A, Heard-Costa NL, Sarnowski C, Raffield LM, Chung J, Marini S, Anderson CD, Rosand J, Xu H, Sun X, Kelly TN, Wong Q, Lange LA, Rotter JI, Correa A, Vasan RS, Seshadri S, Rich SS, Do R, Loos RJF, Longstreth WT Jr, Bis JC, Psaty BM, Tirschwell DL, Assimes TL, Silver B, Liu S, Jackson R, Wassertheil-Smoller S, Mitchell BD, Fornage M, Auer PL, Reiner AP, Kooperberg C.

Stroke. 2021 Nov 3:STROKEAHA120031792. doi: 10.1161/STROKEAHA.120.031792. Online ahead of print.

PMID: 34727735

 

A New Governance Approach to Regulating Human Genome Editing. 

Conley JM, Davis AM, Henderson GE, Juengst ET, Meagher KM, Walker RL, Waltz M, Cadigan J.

N C J Law Technol. 2020 Dec;22(2):107-141.

PMID: 34737680 Free PMC article.

 

Evaluation of the long-term treatment effects of intravenous idursulfase in patients with mucopolysaccharidosis II (MPS II) using statistical modeling: data from the Hunter Outcome Survey (HOS). 

Muenzer J, Botha J, Harmatz P, Giugliani R, Kampmann C, Burton BK.

Orphanet J Rare Dis. 2021 Oct 30;16(1):456. doi: 10.1186/s13023-021-02052-4.

PMID: 34717704 Free PMC article.

 

Integrative analysis reveals mouse strain-dependent responses to acute ozone exposure associated with airway macrophage transcriptional activity. 

Tovar A, Crouse WL, Smith GJ, Thomas JM, Keith BP, McFadden KM, Moran TP, Furey TS, Kelada SNP.

Am J Physiol Lung Cell Mol Physiol. 2021 Nov 10. doi: 10.1152/ajplung.00237.2021. Online ahead of print.

PMID: 34755540

 

Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants. 

Li H, Mattingly AE, Jania LA, Smith R, Melander RJ, Ernst RK, Koller BH, Melander C.

ACS Infect Dis. 2021 Nov 9. doi: 10.1021/acsinfecdis.1c00463. Online ahead of print.

PMID: 34752055

 

Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. 

Bhattacharya R, Zekavat SM, Haessler J, Fornage M, Raffield L, Uddin MM, Bick AG, Niroula A, Yu B, Gibson C, Griffin G, Morrison AC, Psaty BM, Longstreth WT, Bis JC, Rich SS, Rotter JI, Tracy RP, Correa A, Seshadri S, Johnson A, Collins JM, Hayden KM, Madsen TE, Ballantyne CM, Jaiswal S, Ebert BL, Kooperberg C, Manson JE, Whitsel EA; NHLBI Trans-Omics for Precision Medicine Program, Natarajan P, Reiner AP.

Stroke. 2021 Nov 8:STROKEAHA121037388. doi: 10.1161/STROKEAHA.121.037388. Online ahead of print.

PMID: 34743536

 

Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma. 

Laughery MF, Brown AJ, Bohm KA, Sivapragasam S, Morris HS, Tchmola M, Washington AD, Mitchell D, Mather S, Malc EP, Mieczkowski PA, Roberts SA, Wyrick JJ.

Cell Rep. 2020 Nov 17;33(7):108401. doi: 10.1016/j.celrep.2020.108401.

PMID: 33207206 Free PMC article.

 

Model-based assessment of mammalian cell metabolic functionalities using omics data. 

Richelle A, Kellman BP, Wenzel AT, Chiang AWT, Reagan T, Gutierrez JM, Joshi C, Li S, Liu JK, Masson H, Lee J, Li Z, Heirendt L, Trefois C, Juarez EF, Bath T, Borland D, Mesirov JP, Robasky K, Lewis NE.

Cell Rep Methods. 2021 Jul 26;1(3):100040. doi: 10.1016/j.crmeth.2021.100040. Epub 2021 Jun 30.

PMID: 34761247 Free PMC article.

 

Improved Metabolite Prediction Using Microbiome Data-Based Elastic Net Models. 

Xie J, Cho H, Lin BM, Pillai M, Heimisdottir LH, Bandyopadhyay D, Zou F, Roach J, Divaris K, Wu D.

Front Cell Infect Microbiol. 2021 Oct 25;11:734416. doi: 10.3389/fcimb.2021.734416. eCollection 2021.

PMID: 34760716 Free PMC article.

 

Insights and lessons learned from a prospective clinical pharmacology study in allogeneic hematopoietic stem cell transplant during the COVID-19 pandemic. 

Zhu J, Rao G, Armistead PM, Ptachcinski J, Weiner DL, Wiltshire T, Crona DJ.

Clin Transl Sci. 2021 Nov 7. doi: 10.1111/cts.13177. Online ahead of print.

PMID: 34743423 No abstract available.