Category: Research News
New Trial Highlights Incremental Progress Towards a Cure for HIV-1
Cynthia L. Gay, MD, MPH, associate professor of infectious diseases, and David Margolis, MD, the Sarah Kenan Distinguished Professor of Medicine, Microbiology & Immunology, and Epidemiology in the UNC School of Medicine, published results of a clinical trial showing that vorinostat and immunotherapy may modestly shrink the latent HIV reservoir. Cindy Gay, MD, MPH Antiretrovir … Read more
Department of Medicine Grants & Funding: January 1 – January 31, 2024
Division of Oncology Lisa Carey, MD, received a $225K grant titled, “Clinical implications of metastatic subtype, microenvironment, and organ of involvement.” Joannie Ivory, MD, was granted $240K for her project, “Participant Enrollment in a Multi-Site Randomized Clinical Trial of Endocrine Therapy Adherence Support.” Yara Abdou, MD, was awarded $240K to investigate molecular res … Read more
Metformin Use Shows No Increase in Gastrointestinal Adverse Events During GLP-1RA Initiation
A recent study analyzing data from four pivotal clinical trials—LEADER, STEP 2, SUSTAIN 6, and PIONEER 6—evaluated the impact of concomitant metformin use on gastrointestinal adverse events during the initiation and titration of glucagon-like peptide 1 receptor agonists (GLP-1RA). Klara Klein, MD, PhD Klara Klein, MD, PhD, assistant professor of medicine in the UNC Division of En … Read more
First comprehensive medical guideline on management of pouchitis released
Edward Barnes, MD, MPH, co-first author, is an assistant professor in the Division of Gastroenterology and Hepatology and John Haydek, MD, MSCS, author, is an advanced inflammatory bowel diseases fellow. Drs. Barnes and Haydek The American Gastroenterological Association (AGA) has released the first comprehensive evidence-based guideline on the management of pouchitis, the most c … Read more
UNC Researchers Reveal Prevalence of Persistent Symptoms in Patients with Microscopic Colitis
A new study led by Walker Redd, MD, at the UNC School of Medicine, examines how multiple factors contribute to the miscommunication and understanding of the digestive disease, microscopic colitis. Walker Redd, MD It’s a hidden cause of diarrhea and the development of the disease is poorly understood. Multiple factors work against the diagnosis of microscopic colitis, an inflammat … Read more
Removing the Penicillin Allergic Label: Researchers Introduce PADME
Doctors at the UNC School of Medicine, including Mildred Kwan, MD, PhD, and Cincinnati Children’s collaborate to develop an innovative, patient-initiated online platform designed to remove the penicillin allergy label from misdiagnosed pediatric patients. Here’s the scene. Your child appears to be sick. You take their temperature. Fever is over 100. Their throat hurts. You immedi … Read more
GIE Medical Announces First Patient Enrolled in PATENT-E Benign Esophageal Stricture Treatment Study
The large, multicenter randomized controlled clinical trial is evaluating the safety and efficacy of the ProTractX3™ TTS drug coated balloon for the treatment of benign esophageal strictures. News provided by GIE Medical via PRNewswire. MINNEAPOLIS – GIE Medical, a clinical stage company developing solutions for patients suffering from benign stricture(s) of the esophagus or bowe … Read more
Basch receives $3 million research award to launch national patient-reported outcomes project
The Patient-Centered Outcomes Research Institute (PCORI) has awarded UNC Lineberger’s Ethan Basch, MD, MSc, FASCO, $3 million in research funding to support a multi-institutional initiative to implement electronic patient-reported outcomes, or ePRO, in oncology practices across the country. “People being treated for cancer often experience a range of symptoms that can cause distr … Read more
Department of Medicine Grants & Funding: November 1 – November 30, 2023
Division of Hematology Rafal Pawlinski, PhD, and Brandi Reeves, MD, were awarded a one-year $75,000 UNC School of Medicine Phase 2 Translational Team Science Award (TTSA) for their project, “evaluating the role of hypoxia inducible factors in endothelial and hematopoietic cells in myeloproliferative neoplasms.” Division of Endocrinology & Metabolism Emily Pfaff, PhD, spoke ab … Read more
Novel study finds aspirin-free regimen benefits patients with LVAD
The ARIES-HM3 Randomized Clinical Trial assessed the safety and efficacy of excluding aspirin from the antithrombotic regimen in patients with advanced heart failure who have undergone implantation of a fully magnetically levitated left ventricular assist device (LVAD). “There has been no consensus in the field about use of or dose of aspirin in the LVAD population until this stu … Read more
Nelson Expresses Concern for Use of Methotrexate in Hand OA Following Clinical Trial
“Many individuals with hand OA have multiple medical comorbidities and polypharmacy, which are important when considering additional treatments, particularly those with modest benefit and potential adverse effects over the long term,” she said.
Department of Medicine Grants & Funding: October 1 – October 31, 2023
Division of Infectious Diseases Edward P Browne, PhD, received a: R61 grant from the NIDA to examine the impact of cannabinoids in HIV infected humanized mice. This is a five year, $3,465,157 grant. R21 grant from the NIAID to examine post therapy changes in CD4 T cells by single cell RNA sequencing. This award is $427,625. Nicholas Piazza, MD, received a $350,351 grant to intro … Read more