Dr. Guzmán successfully defended his PhD thesis, “Characterizing RNA G-quadruplex Recognition by Disordered Domains of RNA-Binding Proteins,” under the guidance of Dr. Daniel Dominguez.
Publications
Guzmán, B. B.*, Goda, G. A.*, Jimenez, A., Martyr, J. G., Hu, Y., Cavazos, F. F., Aleman, M. M., & Dominguez, D. (2025). Contributions of Folded and Disordered Domains to RNA Binding by HNRNPR. bioRxiv, 2025.05.01.651718. https://doi.org/10.1101/2025.05.01.651718
Martyr, J. G.*, Guzmán, B. B.*, Hu, Y., Rothacher, R. L., Mustoe, A. M., Aleman, M. M., & Dominguez, D. (2025). Massively parallel characterization of RNA G-quadruplex stability and molecular recognition. bioRxiv, 2025.04.29.651304. https://doi.org/10.1101/2025.04.29.651304
Gentile, G. M., Blue, R. E., Goda, G. A., Guzman, B. B., Szymanski, R. A., Lee, E. Y., Engels, N. M., Hinkle, E. R., Wiedner, H. J., Bishop, A. N., Harrison, J. T., Zhang, H., Wehrens, X. H. T., Dominguez, D., & Giudice, J. (2025). Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases. RNA Biology, 15476286.2025.2491160. https://doi.org/10.1080/15476286.2025.2491160
Moffatt, C., Arora, A., Vaeth, K. F., Guzman, B. B., Bhardwaj, G., Hoelscher, A., Gifford, L. B., Russ, H. A., Dominguez, D., & Taliaferro, J. M. (2025). TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stability. bioRxiv. https://doi.org/10.1101/2025.02.25.640092
Harris, S. E., Hu, Y., Bridges, K., Cavazos, F. F., Martyr, J. G., Guzmán, B. B., Murn, J., Aleman, M. M., & Dominguez, D. (2025). Dissecting RNA selectivity mediated by tandem RNA-binding domains. The Journal of Biological Chemistry, 108435. https://doi.org/10.1016/j.jbc.2025.108435
Sahoo, B. R., Kocman, V., Clark, N., Myers, N., Deng, X., Wong, E. L., Yang, H. J., Kotar, A., Guzman, B. B., Dominguez, D., Plavec, J., & Bardwell, J. C. A. (2024). Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation. Nucleic Acids Research, 52(8), 4702–4722. https://doi.org/10.1093/nar/gkae229
Zhuang, F., Gutman, D., Islas, N., Guzman, B. B., Jimenez, A., Jewell, S., Hand, N. J., Nathanson, K., Dominguez, D., & Barash, Y. (2024). G4mer: An RNA language model for transcriptome-wide identification of G-quadruplexes and disease variants from population-scale genetic data. bioRxiv. https://doi.org/10.1101/2024.10.01.616124
Sahoo, B. R., Deng, X., Wong, E. L., Clark, N., Yang, H., Subramanian, V., Guzman, B. B., Harris, S. E., Dehury, B., Miyashita, E., Hoff, J. D., Kocaman, V., Saito, H., Dominguez, D., Plavec, J., & Bardwell, J. C. A. (2023). Visualizing liquid-liquid phase transitions. bioRxiv. https://doi.org/10.1101/2023.10.09.561572
Pimenta, F. M., Huh, J., Guzman, B., Amanah, D., Marston, D. J., Pinkin, N. K., Danuser, G., & Hahn, K. M. (2023). Rho MultiBinder, a fluorescent biosensor that reports the activity of multiple GTPases. Biophysical Journal, 122(18), 3646–3655. https://doi.org/10.1016/j.bpj.2023.04.020
Guzman, B. B.*, Son, A.*, Litberg, T. J.*, Huang, Z.*, Dominguez, D., & Horowitz, S. (2023). Emerging roles for G-quadruplexes in proteostasis. The FEBS Journal, 290(19), 4614–4625. https://doi.org/10.1111/febs.16608
Hinkle, E. R., Wiedner, H. J., Torres, E. V., Jackson, M., Black, A. J., Blue, R. E., Harris, S. E., Guzman, B. B., Gentile, G. M., Lee, E. Y., Tsai, Y.-H., Parker, J., Dominguez, D., & Giudice, J. (2022). Alternative splicing regulation of membrane trafficking genes during myogenesis. RNA, 28(4), 523–540. https://doi.org/10.1261/rna.078993.121
Guzman, B. B., Schauer, A. P., Dunn, J. A., Cottrell, M. L., & Sykes, C. (2021). A quantitative LC–MS/MS method for the determination of tissue brincidofovir and cidofovir diphosphate in a MuPyV‐infected mouse model. Biomedical Chromatography, 35(5), e5061. https://doi.org/10.1002/bmc.5061
Goering, R., Hudish, L. I., Guzman, B. B., Raj, N., Bassell, G. J., Russ, H. A., Dominguez, D., & Taliaferro, J. M. (2020). FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences. eLife, 9, e52621. https://doi.org/10.7554/eLife.52621
Sykes, C., Blake, K., White, N., Schauer, A. P., Guzman, B. B., Cottrell, M. L., Tamraz, B., & Kashuba, A. D. M. (2018). Development and validation of an LC-MS/MS assay for the quantification of dolutegravir extracted from human hair. Analytical and Bioanalytical Chemistry, 410(29), 7773–7781. https://doi.org/10.1007/s00216-018-1394-y
Congratulations, Bryan, we wish you all the best!