Dr. Welsh successfully defended her PhD Thesis, “Regulating the Anaphase-Promoting Complex/Cyclosome (APC/C): Intrinsic Mechanisms and Cell Cycle Inhibitors” under the guidance of Dr. Nicholas Brown.
Publications
The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment. Ledvin L, Gassaway BM, Tawil J, Urso O, Pizzo D, Welsh KA, Bolhuis DL, Fisher D, Bonni A, Gygi SP, Brown NG, Ferguson CJ. Dev Cell. 2023 Dec 4;58(23):2666-2683.e9. doi: 10.1016/j.devcel.2023.10.002. Epub 2023 Oct 23. PMID: 37875116. PMC10872926
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Bodrug T, Welsh KA, Bolhuis DL, Paulаkonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG. Nat Struct Mol Biol. 2023 Nov;30(11):1663-1674. doi: 10.1038/s41594-023-01105-5. Epub 2023 Sep 21. PMID: 37735619 . PMC10643132
Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1. Bolhuis DL*, Martinez-Chacin RC*, Welsh KA*, Bodrug T, Cui L, Emanuele MJ, Brown NG. Protein Sci. 2022 Jun;31(6):e4324. doi: 10.1002/pro.4324. PMID: 35634770. PMC9112349
Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes. Welsh KA*, Bolhuis DL*, Nederstigt AE, Boyer J, Temple BRS, Bonacci T, Gu L, Ordureau A, Harper JW, Steimel JP, Zhang Q, Emanuele MJ, Harrison JS, Brown NG. EMBO J. 2022 Feb 1;41(3):e108823. doi: 10.15252/embj.2021108823. Epub 2021 Dec 23. PMID: 34942047. PMC8804933
Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation. Bodrug T*, Welsh KA*, Hinkle M, Emanuele MJ, Brown NG. Front Cell Dev Biol. 2021 May 24;9:687515. doi: 10.3389/fcell.2021.687515. eCollection 2021. PMID: 34109183. PMC8182066
*These authors contributed equally
Dr. Welsh is also an author on a paper that has been accepted by Nature Communications which will be published shortly.
Honors, Awards & Highlights
American Heart Association Award, January 2023
Kaeli Welsh, PhD student in Nicholas Brown’s lab, received the Pre-doctoral Fellowship for her project, “Visualizing Essential Molecular Mechanisms That Promote Mitotic Exit.”
Kaeli Welsh featured scholar in Carolina Grad Student F1rsts, April 2021
Congratulations to graduate student, Kaeli Welsh (Brown Lab) for being a Carolina Grad Student F1rsts featured scholar!
Pharmacology Thomas Collum Butler Award, December 2022
The Thomas Collum Butler Award recognizes the outstanding work of a PhD or MD/PhD PHCO Graduate Student currently working in a core or joint PHCO lab. Selection is on the basis of merit.
Congratulations, Kaelie, we wish you all the best!