Dr. de Castro successfully defended his Phd thesis, Neuroimmune Mechanisms of Adolescent Alcohol-Induced Neuropathology” under the guidance of Dr. Ryan Vetreno!”
The full title of Dr. de Castro’s defense presentation was, “Neuroimmune Mechanisms of Adolescent Alcohol-Induced Neuropathology: From Epigenetic Repression to Retrotransposon Activation, Behavioral Outcomes, and Genetic Vulnerability.”
Publications
Impact of Neuroimmune System Activation by Adolescent Binge Alcohol Exposure on Adult Neurobiology. Macht V, de Castro S, Vetreno RP. Adv Exp Med Biol. 2025;1473:179-208. doi: 10.1007/978-3-031-81908-7_9. PMID: 40128480.
Microglia either promote or restrain TRAIL-mediated excitotoxicity caused by Aβ1-42 oligomers. Zou J, McNair E, DeCastro S, Lyons SP, Mordant A, Herring LE, Vetreno RP, Coleman LG Jr. J Neuroinflammation. 2024 Sep 1;21(1):215. doi: 10.1186/s12974-024-03208-2. PMID: 39218898. PMC11367981
In Vitro Antimalarial Activity of Trichothecenes against Liver and Blood Stages of Plasmodium Species. Parvatkar PT, Maher SP, Zhao Y, Cooper CA, de Castro ST, Péneau J, Vantaux A, Witkowski B, Kyle DE, Manetsch R. J Nat Prod. 2024 Feb 23;87(2):315-321. doi: 10.1021/acs.jnatprod.3c01019. Epub 2024 Jan 23. PMID: 38262446. PMC10897926
Synthesis of Mono- and Bisperoxide-Bridged Artemisinin Dimers to Elucidate the Contribution of Dimerization to Antimalarial Activity. Lichorowic CL, Zhao Y, Maher SP, Padín-Irizarry V, Mendiola VC, de Castro ST, Worden JA, Casandra D, Kyle DE, Manetsch R. ACS Infect Dis. 2021 Jul 9;7(7):2013-2024. doi: 10.1021/acsinfecdis.1c00066. Epub 2021 Apr 1. PMID: 33792305. PMC9247344
Honors, Awards & Highlights
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I was a team lead and semifinalist in the 2026 Southeastern Case Competition
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I was inducted into Sigma Xi in 2025
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I was a best poster finalist at the Triangle Society for Neuroscience in 2024
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I gave a talk at the Society for Neuroscience Scientific Meeting in 2024
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I was named an inventor on an international patent on Tetrahydroacridinone Analogs for the Treatment and Prevention of Malaria (WO2024258904A1)
We wish you all the best, Sagan!