- epigenetic control by long noncoding RNAs, genomics, stem cells, cancer, human genetic disorders
Long-term goals of the Calabrese laboratory are to determine the nuclear functions and molecular mechanisms of long noncoding RNAs (lncRNAs), and to develop methods to modulate lncRNA function for therapeutic gain. Projects in the lab include: mechanisms of RNA-mediated recruitment of Polycomb complexes to chromatin, mechanisms of gene silencing by Xist and Xist-like lncRNAs, mechanisms of lncRNA homeostasis with relation to gene control in cancer, discovery of novel regulatory RNAs, control of lncRNA regulatory function through cellular signaling pathways, and developing new methods to predict relationships between lncRNA sequence and regulatory function. We use a combination of genomics, genetics, molecular and cell biology, biochemistry, and computational biology to achieve our research objectives.
Motivated graduate students and post-doctoral fellows interested in joining the group are encouraged to contact Dr. Calabrese via email.