News
Structural and Functional Connectome Relationships in Early Childhood
We investigate the development of cortical structure-function coupling in children longitudinally scanned at 1, 2, 4, and 6 years old. We found that regional patterns of structure-function coupling in early childhood that were consistent with adult patterns.
Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression
In the largest analysis of postpartum depression (PPD) genetics, we have provided estimates of the genetic contribution to this debilitating disorder. Also, we have shown that PPD has similar genetics to other psychiatric traits. Lastly, PPD associated genetic regions may affect neurons also targeted recently approved therapeutics specifically for PPD (Brexanolone and Zuranolone).
Prenatal stress unmasks behavioral phenotypes in genetic mouse models of neurodevelopmental disorders
Two-hit models of neurodevelopmental disorders have the power to reveal underlying vulnerability that may not be detected in studies employing only genetic or environmental alterations. In this review, we summarize existing literature that investigates detrimental interactions between prenatal stress and genes associated with neurodevelopmental disorders, with a focus on behavioral phenotyping approaches in mouse models.
Crowd-sourced investigation of a potential relationship between Bartonella-associated cutaneous lesions and neuropsychiatric symptoms
Investigation of the extent to which rashes associated with Bartonella infection are associated with symptoms of depression, anxiety and schizotypy.
Youth Behavioral Hospital Ribbon Cutting Ceremony
The mental health of our children and adolescents is perhaps the largest issue affecting the future health of our state. UNC Health has partnered with the N.C. Department of Health and Human Services to convert the R.J. Blackley Alcohol and Drug Abuse Treatment Center in Granville County into a 54-bed inpatient psychiatric hospital for children … Read more