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The research showed early deletion of Ccr2 in aggrecan-expressing cells reduces the initiation, but not the progression, of post traumatic osteoarthritis and its associated pain.

You can view the article published in Osteoarthritis and Cartilage here:
“Early ablation of Ccr2 in Aggrecan-expressing cells Following Knee Injury Ameliorates Joint Damage and Pain during Post-traumatic Osteoarthritis.”