"The Skeleton in a Physical World" Brief Description: All organisms exist within a physical space and respond to physical forces as part of daily life. The skeleton responds in real-time to physical stresses placed on it to ensure that its structure supports its function. I will discuss how those cells responsible for remodeling skeletal structure … Read more
After two years of meeting virtually, we are excited to once again host Research Day 2022 in person.* *(In-person attendance pending potential changes in University policies due to COVID-19.) All presenters will host their sessions in person. For certain events there will be a virtual/Zoom option, for attendees unable to attend in person. Be sure … Read more
Presentation Title: "Orthopedic Translational Medicine: Horses, Humans and the Pursuit of Joint Health" Brief description: Post-traumatic Osteoarthritis (PTOA) is extremely common in equine athletes as well as humans. The horse is an incredible translational model and has been utilized for decades to inform equine clinicians treating their patients and MD’s treating people with PTOA. Further, … Read more
"Genomic Approaches to Understanding the Genetic Risk of Osteoarthritis" Genome-wide association studies (GWAS) have identified over 100 osteoarthritis (OA)-associated loci; however, translating these broad loci into actionable therapeutic targets requires identifying the causal variants, the gene(s) they affect, and their mechanistic impact on OA risk. We apply genomic, bioinformatics, and genome editing approaches to identify … Read more
Proteostasis: Does it have a role in osteoarthritis? Brief description: Loss of proteostasis is one of the hallmarks of aging. We found that aging reduces the expression of molecular chaperones in chondrocytes resulting in cellular stress and inflammation, which could contribute to the development of osteoarthritis. Dr. Raghunatha Yammani Associate Professor, Molecular Medicine Wake Forest … Read more
"A new approach to infectious arthritis: understanding bacterial behavior in synovial fluid and developing a novel therapeutic" Brief Description: This seminar will highlight our group's work on how and why bacteria form free-floating biofilms in synovial fluid including our ex-vivo model system. The seminar will then focus on our development of a novel therapeutic, BIO-PLY, … Read more
"Wandering in the sciences; from nanotechnology, to sustainable oceans, to a new cancer immunotherapy" Chris Kepley, PhD Associate Professor, Nanoscience University of NC, Greensboro Virtual (Zoom) URL: https://zoom.us/j/92101985767?pwd=d3hHbWhHMFlQSm05RmdCVVVmMkVIUT09 Meeting ID: 921 0198 5767 Passcode: 005755 Phone (New York): 929-205-6099 Phone (Toll-free): 888-475-4499