Gang (Greg) Wang

Research keywords: chromatin modification, histone, DNA methylation, epigenetics, cancer

Gang (Greg) Wang

Assistant Professor of Biochemistry and Biophysics
(PhD - University of California, San Diego)

ACCEPTING STUDENTS

450 West Drive, CB# 7295
31-327 Lineberger Cancer Center
Chapel Hill, NC 27599-7260
919-966-5952

Wang Lab website

HONORS & AWARDS

  • Leukemia & Lymphoma Society Scholar Award 2018
  • Gilead Sciences Research Scholars Award: 2017
  • American Cancer Society (ACS) Research Scholar: 2016
  • CONquer canCER Now! (Concern) Foundation Junior Faculty Award: 2014
  • Career Development Award, Department of Defense (DoD) & USA Army: 2014
  • Kimmel Scholar Award: 2014

RESEARCH SUMMARY

Our research interests focus broadly on the role for chromatin modification and epigenetic mechanism in gene regulation, development and disease, notably cancer. Our recent works in this broad field have shown that dysregulation of enzymes and effectors involved in histone and DNA methylation causally leads to gene expression deregulation and cancer development. We favor a general view that human disease including cancer often arises from dysregulation of an “epigenetic language” embedded in the genome, when it is mis-written, mis-erased or mis-interpreted. Currently, our laboratory employs cutting-edge techniques, which include CRISPR/cas9-based genomic editing, deep sequencing and small-molecule epigenetic inhibitors, to address issues relating to fundamentals of epigenetics and cancer therapeutics. Multiple on-going projects are (1) biochemical characterization of novel factors/complexes that read chromatin modification; (2) CRISPR/dCas9-based editing of epigenomic modifications for understanding their roles in gene function; (3) knockout and knock-in mouse models with deficiency in chromatin regulators in context of development and tumorigenesis; (4) epigenomic and transcriptome analyses (ChIP-Seq and RNA-Seq) of normal versus cancer cells to delineate pathways essential for tumor growth.

SELECTED PUBLICATIONS

  • Zhang ZM*, Lu R*, Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG#, Song J#. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature. 2018 Feb 7. doi: 10.1038/nature25477. #, correspondence author. [Highlighted in Cancer Discovery].

  • Xu B, Cai L, Bulter J, Chen D, Lu X, Joel PS, Rafii S, Zheng D, Wang GG#. The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports 2018 March 13. 10: 1-9.

  • Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen WY, Abdel-Wahab O, Wade PA, Zheng D#, Wang GG#. Epigenetic perturbations by Arg882-mutated DNMT3A potentiate aberrant stem cell gene expression program and acute leukemia development. Cancer Cell2016 July 11; 30(1):92-107.  #, corresponding author.

  • Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GG#.  Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 2015 Jan 8;125(2):346-57. PMCID: PMC4287641.
  • Cai L, Rothbart SB, Lu R, Xu B, Chen WY, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J#, Wang GG#.   An H3K36 methylation engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell. 2013 Feb 7;49(3):571-82. PMID: 23273982.
  • Chi P, Allis CD# and Wang GG#.  Covalent histone modifications: mis-written, mis-erased and mis-interpreted in human cancers. Nat Rev Cancer. 2010,10(7):457-69. PMID: 20574448.
  • Wang GG, Song J, Wang Z, Dormann HL, Casadio F, Li H, Luo J, Patel DJ and Allis CD#. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature. 2009, 459(7248):847-851. PMID: 20541251.

Link to all pubs

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