Qisheng Zhang

Nancy Allbritton

Assoicate Professor

Chemical Biology and Medicinal Chemistry, School of Pharmacy

Ph.D., Organic Chemistry
University of Pittsburgh

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School of Pharmacy
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Research Interests

  • Lipid signaling and small GTPases  

Research Synopsis

Our research interest is focused on understanding the roles of endogenous small molecules, particularly the phosphatidylinositides (PIs), in cell signaling events that are responsible for both normal development and diseases. PIs are one of the most versatile signaling molecules, yet are difficult to study due to their dynamic metabolism in the cells and the lack of available reagents and assays for PIs and their metabolic enzymes. Consequently, how PI signaling pathways regulate normal development and diseases is still poorly understood. We are interested in three different approaches to address this question: 1) develop efficient methods and technologies to synthesize PIs and identify their interacting proteins; 2) develop small molecule sensors and inhibitors for different PI metabolic enzymes; and 3) investigate the cellular functions of known and unknown PIs, particularly how PIs synergize with small GTPases in regulating signal transduction. 

Publications

pubmed

 Click above for PubMed publications.

Huang, W.; Barrett, M.; Hicks, S.; Hajicek, N.; Sondek, J.; Harden, T. K.; Zhang, Q.* (2013) Small Molecule PLC Inhibitors from a Novel High Throughput Screen. J. Biol. Chem. 288: 5840-5848. Abstract

Wang, X.; Barrett, M.; Sondek, J.; Harden, T. K.; Zhang, Q.* (2012) Fluorescent Phosphatidylinositol 4,5-Bisphosphate Derivatives with Modified 6-Hydroxy Group as Novel Substrates for Phospholipase C. Biochemistry  51: 5300-5306. Abstract

Song, Z.; Huang, W.; Zhang, Q.* (2012) Isotope-coded, Fluorous Photoaffinity Labeling Reagents. Chem. Commun. 48: 3339-3341. Abstract

Sun, W.; Vanhooke, J.; Sondek, J.; Zhang, Q.* (2011) High Throughput Fluorescence Polarization Assay for the Enzymatic Activity of GTPase-activating Protein of ADP-ribosylation Factor (ARFGAP). J. Biomol. Screen. 16: 717-723. Abstract

Huang, W.; Hicks, S. N.; Sondek, J.; Zhang, Q.* (2011) A Fluorogenic, Small Molecule Reporter for Mammalian Phospholipase C Isozymes. ACS Chem. Biol. 6: 223-228. Abstract


Contact Information

 
Office Location:
2020 Genetic Medicine Bldg

Mailing Address:
CB # 7363
UNC Eshelman School of Pharmacy
Chapel Hill, NC 27599-7363

Office Phone: 919-966-9687
Lab Phone: 919-966-9137
Fax: 919-962-2388
qszhang[at]unc.edu

 

 

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