Congratulations to Dr. Ryan Vetreno, Assistant Professor of Psychiatry and a member of the Bowles Center for Alcohol Studies, on receiving a grant award from the Foundation of Hope, an organization committed to supporting groundbreaking research on the biological, neurological, and genetic bases of mental illness and paving the way for improved treatment and diagnostic methods to emerge. The grant will support Dr. Vetreno’s research on novel epigenetic and plasticity mechanisms that have therapeutic potential for the treatment of alcohol use disorder (AUD) and other psychiatric disorders associated with neuroinflammation. The proposed studies intend to fill a critical gap in research surrounding the role that epigenetic modifications play in persistent microglial phenotype changes that are induced by adolescent binge alcohol drinking, in addition to its potential impact on proinflammatory neuroimmune signaling that persists into adulthood in association. with lasting neuropathology that are reversible. Reversibility of microglial proinflammatory phenotype and proinflammatory signaling opens opportunities for potential restorative therapies targeting risk factors for AUD as well as a broad range of neurodevelopmental and neurodegenerative diseases.