Publication News! “Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with a Fga truncation mutation”
Woosuk Steve Hur, PhD of the Flick Laboratory is the first author of a manuscript accepted for publication in Blood
In this collaborative study involving several UNC BRC labs (Flick, Bergmeier and Wolberg), Hur et al., determined the impact of genetically- or pharmacologically-imposed hypofibrinogenemia on hemostasis, thrombosis and fibrinogen-dependent antimicrobial function in newly generated and characterized mouse models. The authors determined that reduction of fibrinogen to ~10 of normal circulating levels was sufficient to preserve hemostasis and fibrinogen-mediated antimicrobial function, but this reduction prevented venous thrombosis in an inferior vena cava ligation model. Their work suggests a novel method to prevent and/or treat thrombosis without inducing significant bleeding complications: lowering circulating fibrinogen levels.
Read the Full Publication Here: https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2021012537/483059/Hypofibrinogenemia-with-preserved-hemostasis-and?redirectedFrom=fulltext