Drs. Ra
madas, Trebak, Pawlinski and Sparkenbaugh are co-authors of “Biased agonism of protease-activated receptor-1 regulates thrombo-inflammation in murine sickle cell disease” and their manuscript was accepted in Blood Advances. In this study, they showed that APC inhibition exacerbates thrombin generation, inflammation and end-organ damage in a mouse model of sickle cell disease (SCD), and that APC-PAR1 biased agonism reduces inflammation, suggesting that targeting this pathway may mitigate vascular complications of SCD.