January 9, 2024
Project Title: Evaluation of a C1 inhibitor variant as a novel hemostasis sparing anticoagulant Awardee: Ana Sachetto Mentor: Nigel Mackman Co-mentor: Steven Grover Total amount awarded: $151,564
September 25, 2023
Harish Eswaran, MD and Stephan Moll, MD co-authored a publication in Blood Advances titled Evaluating complement dysregulation in livedoid vasculopathy using a functional assay. Livedoid vasculopathy (LV) is a chronic skin condition characterized by severely painful ulcers that come and go on the legs and feet. LV is caused by thrombosis in the small blood …
September 11, 2023
Steve Hur, PhD, is one of five recipients of the Postdoctoral Awards for Research Excellence from the UNC Office of Postdoctoral Affairs in recognition of research promise demonstrated by individual postdoctoral scholars. He will present his research during University Research Week in October.
September 5, 2023
UNC BRC faculty members Dr. Stephan Moll (adult hematology) and Dr. Baskin-Miller pediatric Hematology-Oncology) and a former UNC Hematology-Oncology trainee (Dr. Alison Raybould, Richmond, VA)) co-authored a recent New England Journal of Medicine publication of a collaborative investigation documenting an association of adeno virus infection with an anti-platelet-factor-4 (PF4) antibody disorder with severe thrombocytopenia and …
August 3, 2023
Click here to read the Special Edition Summer Newsletter 2023
August 2, 2023
Yohei Hisada, PhD & Nigel Mackman, PhD have been published in Blood Advances. Their research paper, Tissue factor activates coagulation in mouse models of acute promyelocytic leukemia, measured the biomarkers of activation of coagulation, fibrinolysis, platelet, and bleeding in two mouse models (allograft and xenograft models) of acute promyelocytic leukemia and investigated the effect of …
August 1, 2023
Brandi Reeves, MD, received a 5-year NHLBI K08 Mentored Clinical Scientist Development Award for a research project evaluating the role of hypoxia inducible factor in myeloproliferative-associated thrombosis. These awards are judged not only on the merit of the candidate, training plan, and the research proposal, but also on institutional environment and mentoring team. Her mentoring …
June 20, 2023
BRC Abstracts for ISTH Montreal 2023
April 1, 2023
Click here to read the April 2023 Newsletter
March 31, 2023
Hemostatic plug formation at sites of vascular injury is strongly dependent on rapid platelet activation and aggregation. However, to prevent thrombotic complications, platelet aggregate formation is regulated, in part, by the desensitization of the platelet P2Y1 receptor. Here, we analyzed a novel knock-in mouse strain expressing a P2Y1 receptor variant that cannot be desensitized. The …
March 27, 2023
Steven Grover, PhD was invited to present on the role of C1 inhibitor in venous thrombosis at the inaugural Immunothrombosis Symposium held at the Center for Advanced Studies of Ludwig Maximilians Universität in Munich. The two day symposium, hosted by Drs Konstantin Stark and Leo Nicolai, brought together researchers with an interest in immunothrombotic pathologies to …
March 26, 2023
Raj Kasthuri, MD co-authored a publication in the Annals of Internal Medicine titled Effect of Thromboprophylaxis on Clinical Outcomes After COVID-19 Hospitalization. Patients hospitalized with COVID-19 have an increased incidence of thromboembolism. The role of extended thromboprophylaxis after hospital discharge is unclear. To determine whether anticoagulation is superior to placebo in reducing death and …