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Mackman Lab Publishes Two Articles https://www.rpthjournal.org/article/S2475-0379(25)00331-0/fulltext https://www.rpthjournal.org/article/S2475-0379(25)00340-1/fulltext “Optimization of a Western blot protocol for the detection of low levels of tissue factor in human cells” The tissue factor (TF)/activated factor VII complex is the major activator of the coagulation system. TF is expressed by a variety of cells, including activated monocytes and tumor cells. …

Meghana Malempati was awarded a UNC Summer Undergraduate Research Fellowship (SURF). The Summer Undergraduate Research Fellowship (SURF) program is one of many programs administered through the OUR, and it is designed to enhance the educational experience of undergraduates by engaging them in research opportunities. We expect to make about 60 individual awards each summer. SURF …

Ana Sachetto PhD was awarded a Top Poster Award and Early Career Travel Award at ISTH 2025 Congress Each year, the ISTH Congress Scientific Committee rewards abstracts of outstanding quality and provides the submitting author with a Travel Award to attend the ISTH Congress. Three categories of Travel Award are distributed: Early Career Awards (165 awards), …

Jane Little, MD, awarded RO1 from NIH Hypoxemia with Sleep in Sickle Cell Anemia-Prevalence, Clinical and Cellular Impact & Response to Therapy: A Multi-Site Prospective Study Accessing New Collaborative Pathways Sickle cell disease (SCD) arises from a gain-of function mutation of hemoglobin (Hb) in which deoxygenated sickle hemoglobin (deoxy-HbS) polymerizes, resulting in rigid, adhesive, and fragile red blood cells (RBCs) …

Alexandra Jane Borst, Clinical Associate Professor, and other team members awarded a large NIH U54 grant which is to support a rare-disease research consortium for vascular anomalies. It has many components and CHOP is the coordinating center, Borst is a PI for one of the main clinical projects, “Developing a Natural History Registry and Biorepository …

Emily Grace Clark, mentored by Dr. Matthew Flick, received an F31 award, “Disrupting the Fibrin Shield to Combat Staphylococcus aureus BloodstreamInfections.”

UNC Hem/Onc Fellow Sam Short, MD and collaborators/mentors from the REGARDS study published two papers in JTH about stroke risk in atrial fibrillation. Improving stroke risk prediction in atrial fibrillation with circulating biomarkers: the CHA2DS2-VASc–Biomarkers model (DOI: 10.1016/j.jtha.2025.06.007) Circulating biomarkers and ischemic stroke risk in adults with atrial fibrillation taking anticoagulation: the Reasons for Geographic And Racial …

Karin Leiderman, PhD and Dougald Monroe, PhD published in JTH. Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions. This study aimed to investigate emicizumab’s lipid-surface dependent mechanisms through mathematical modeling and biochemical assays. Read more here

Erica Sparkenbaugh, PhD appointed the co-chair of the 2029 HTRS Scientific Symposium Planning Committee We are excited to announce the Planning Committee for the HTRS 2027 Scientific Symposium, a dynamic three-day scientific conference dedicated to the advancement of clinical, translational, and discovery-based science research related to disorders of hemostasis and thrombosis. Meet …

Dr Monroe and colleagues published a study on the role of plasma inhibitors in regulating thrombin levels. Dougald Monroe, professor in the UNC Division of Hematology, and colleagues Allen Ma and Maureane Hoffman published their study on the contribution of four plasma inhibitors in regulating thrombin generation. The work was published in Blood Vessels, Thrombosis, …

View BRC August 2025 Newsletter August 2025 Newsletter

photo of matthew karafin, smiling in a suit

Matthew Karafin published the initial results of his prospective randomized clinical trial in JCI. Authors: Matthew S. Karafin, Abby S. Grier, Ross M. Fasano, Anton Ilich, David Wichlan, Ada Chang, Sonjile M. James, Hailly E. Butler, Oleg Kolupaev, Melissa C. Caughey, Daniel Stephenson, Julie A. Reisz, Nigel S. Key, Joshua J. Field, Jane A. Little, Steven L. Spitanik, …

Category: News

Mackman Lab Publishes Two Articles

Meghana Malempati was awarded a UNC Summer Undergraduate Research Fellowship (SURF).

Ana Sachetto PhD was awarded a Top Poster Award and Early Career Travel Award at ISTH 2025 Congress

Jane Little, MD, awarded RO1

Alexandra Jane Borst awarded a large NIH U54 grant

Emily Grace Clark received an F31 award, “Disrupting the Fibrin Shield to Combat Staphylococcus aureus Bloodstream Infections.”

Sam Short, MD and collaborators/mentors from the REGARDS study published two papers in JTH about stroke risk in atrial fibrillation.

Karin Leiderman, PhD and Dougald Monroe, PhD published in JTH

Erica Sparkenbaugh, PhD appointed the co-chair of the 2029 HTRS Scientific Symposium Planning Committee

Dougald Monroe, PhD, Allen Ma, and Maureane Hoffman, PhD MD, published in Blood Vessels, Thrombosis, & Hemostasis.

BRC August 2025 Newsletter

Matthew Karafin, MD MS, published the initial results of his prospective randomized clinical trial in JCI.