November 18, 2025
Graduate students in the Aleman and Dominguez Labs won Abstract Achievement Awards for the upcoming ASH meeting. Kwame Forbes, PhD Candidate in Bioinformatics and Computational Biology for “Decoding the gene regulatory response to iron through multiomics.” Michael Sullivan, PhD Candidate in Pharmacology for “Intracellular iron levels alter the protein interactome of PCBP1.
November 18, 2025
View BRC November 2025 Newsletter November 2025 Newsletter
November 13, 2025
Dr. Aleksei Martianov (PI: Dr. Wolfgang Bergmeier) was awarded the Richard T. Silver, MD Abstract Achievement Award for Myeloproliferative Neoplasms (MPNs). He will give an oral presentation entitled “Platelet priming in MPN triggers pro-thrombotic intermediate affinity state in αIIbβ3 integrin” on Sunday December 7, 2025 at 9:30 AM in Room W304-EFGH. Dr. Nirupama Ramadas (PI: …
November 6, 2025
On October 7, the Pathobiology and Translational Science graduate program had their annual student symposium. BRC trainees presented posters (YJ Choi – Wolberg Lab, Claire Reist – Flick Lab) and one gave a talk (Kylie Hutchison – Sparkenbaugh Lab). Alisa Wolberg, Steve Hur, and Erica were BRC faculty in attendance. We also had several postdocs, …
November 6, 2025
Nirupama Ramadas had a review paper published in RPTH “Emerging pathways in thromboinflammation of sickle cell disease: novel findings in disease pathogenesis” Sickle cell disease (SCD) is increasingly recognized as a chronic thromboinflammatory disorder, marked by persistent intravascular hemolysis, sustained endothelial activation, and multicellular aggregate formation. Free hemoglobin and heme act as damage-associated molecular patterns, …
November 6, 2025
Ana Sachetto PhD is chair of the UNC Postdoctoral Association The PDA is a social and collaborative space where postdoc volunteers come together to discuss relevant issues and try to find ways to improve the postdoc experience for the 800-1000 postdocs on UNC campus at any given time. Our main goals are to foster …
November 6, 2025
Mackman Lab Publishes Two Articles https://www.rpthjournal.org/article/S2475-0379(25)00331-0/fulltext https://www.rpthjournal.org/article/S2475-0379(25)00340-1/fulltext “Optimization of a Western blot protocol for the detection of low levels of tissue factor in human cells” The tissue factor (TF)/activated factor VII complex is the major activator of the coagulation system. TF is expressed by a variety of cells, including activated monocytes and tumor cells. …
November 6, 2025
Meghana Malempati was awarded a UNC Summer Undergraduate Research Fellowship (SURF). The Summer Undergraduate Research Fellowship (SURF) program is one of many programs administered through the OUR, and it is designed to enhance the educational experience of undergraduates by engaging them in research opportunities. We expect to make about 60 individual awards each summer. SURF …
November 6, 2025
Ana Sachetto PhD was awarded a Top Poster Award and Early Career Travel Award at ISTH 2025 Congress Each year, the ISTH Congress Scientific Committee rewards abstracts of outstanding quality and provides the submitting author with a Travel Award to attend the ISTH Congress. Three categories of Travel Award are distributed: Early Career Awards (165 awards), …
October 31, 2025
Jane Little, MD, awarded RO1 from NIH Hypoxemia with Sleep in Sickle Cell Anemia-Prevalence, Clinical and Cellular Impact & Response to Therapy: A Multi-Site Prospective Study Accessing New Collaborative Pathways Sickle cell disease (SCD) arises from a gain-of function mutation of hemoglobin (Hb) in which deoxygenated sickle hemoglobin (deoxy-HbS) polymerizes, resulting in rigid, adhesive, and fragile red blood cells (RBCs) …
October 29, 2025
Alexandra Jane Borst, Clinical Associate Professor, and other team members awarded a large NIH U54 grant which is to support a rare-disease research consortium for vascular anomalies. It has many components and CHOP is the coordinating center, Borst is a PI for one of the main clinical projects, “Developing a Natural History Registry and Biorepository …
October 15, 2025
Emily Grace Clark, mentored by Dr. Matthew Flick, received an F31 award, “Disrupting the Fibrin Shield to Combat Staphylococcus aureus BloodstreamInfections.”