October 3, 2025
Karin Leiderman, PhD and Dougald Monroe, PhD published in JTH. Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions. This study aimed to investigate emicizumab’s lipid-surface dependent mechanisms through mathematical modeling and biochemical assays. Read more here
September 25, 2025
Erica Sparkenbaugh, PhD appointed the co-chair of the 2029 HTRS Scientific Symposium Planning Committee We are excited to announce the Planning Committee for the HTRS 2027 Scientific Symposium, a dynamic three-day scientific conference dedicated to the advancement of clinical, translational, and discovery-based science research related to disorders of hemostasis and thrombosis. Meet …
September 11, 2025
Dr Monroe and colleagues published a study on the role of plasma inhibitors in regulating thrombin levels. Dougald Monroe, professor in the UNC Division of Hematology, and colleagues Allen Ma and Maureane Hoffman published their study on the contribution of four plasma inhibitors in regulating thrombin generation. The work was published in Blood Vessels, Thrombosis, …
August 14, 2025
View BRC August 2025 Newsletter August 2025 Newsletter
August 7, 2025
Matthew Karafin published the initial results of his prospective randomized clinical trial in JCI. Authors: Matthew S. Karafin, Abby S. Grier, Ross M. Fasano, Anton Ilich, David Wichlan, Ada Chang, Sonjile M. James, Hailly E. Butler, Oleg Kolupaev, Melissa C. Caughey, Daniel Stephenson, Julie A. Reisz, Nigel S. Key, Joshua J. Field, Jane A. Little, Steven L. Spitanik, …
July 30, 2025
Please join us for our Fall 2025 Blood Research Center Seminar Series, happening at 11am. Follow us on Linkedin for more information
July 25, 2025
Kylie Hutchison, a rising 2nd year PhD student within the Pathobiology and Translational Science program, was accepted into the UNC Certificate Program in Translational Medicine and selected as 1 of 4 trainees to receive funding from the certificate’s T32 training grant from the National Institute for General Medical Sciences (NIGMS) (NIH T32GM122741). This certificate program provides specialized …
June 10, 2025
Published article in Biophys Journal: Modeling platelet P2Y1/12 pathway to integrin activation. Authors: Patel KB, Bergmeier W, Fogelson AL.
June 10, 2025
Published article in JTH: Lack of overt bleeding or platelet dysfunction in a mouse model of vascular Ehlers-Danlos syndrome. Authors: Lee RH, Jones SR, Martyanov AA, Vander Ploeg MR, Sagues CF, Bergmeier W.
June 5, 2025
UNC’s Vital Signs highlighted work from the Wolberg laboratory (https://news.unchealthcare.org/2025/05/unc-study-offers-new-hope-for-safer-bleeding-treatments/) that is currently in press in Blood (https://ashpublications.org/blood/article/doi/10.1182/blood.2025028680/537391/Plasminogen-activation-and-plasmin-activity-are). This work showed that plasminogen activation and activity are not required to prevent venous thrombosis/thromboembolism, and suggests that use of antifibrinolytic therapy to decrease bleeding is not expected to increase thrombosis risk. This work was first authored …
June 5, 2025
Dr. Yaqiu Sang, a postdoctoral fellow in Dr. Wolberg’s laboratory was featured in the Brinkhous Bulletin, the Department of Pathology and Laboratory Medicine’s monthly newsletter that reports exciting developments in the department. Dr. Sang was highlighted for her her contributions to the Wolberg lab including her recent paper published in Blood (https://ashpublications.org/blood/article/doi/10.1182/blood.2025028680/537391/Plasminogen-activation-and-plasmin-activity-are).
June 5, 2025
Read more on this Case Study An 8-year-old female with sickle cell disease (SCD), hemoglobin SS genotype, global developmental delay, and pica established care shortly after moving from out of state. The patient and her family had been living in a weathered house. The child’s caregiver reported a recent history of weakness in the right …