October 31, 2025
Jane Little, MD, awarded RO1 from NIH Hypoxemia with Sleep in Sickle Cell Anemia-Prevalence, Clinical and Cellular Impact & Response to Therapy: A Multi-Site Prospective Study Accessing New Collaborative Pathways Sickle cell disease (SCD) arises from a gain-of function mutation of hemoglobin (Hb) in which deoxygenated sickle hemoglobin (deoxy-HbS) polymerizes, resulting in rigid, adhesive, and fragile red blood cells (RBCs) …
October 29, 2025
Alexandra Jane Borst, Clinical Associate Professor, and other team members awarded a large NIH U54 grant which is to support a rare-disease research consortium for vascular anomalies. It has many components and CHOP is the coordinating center, Borst is a PI for one of the main clinical projects, “Developing a Natural History Registry and Biorepository …
October 15, 2025
Emily Grace Clark, mentored by Dr. Matthew Flick, received an F31 award, “Disrupting the Fibrin Shield to Combat Staphylococcus aureus BloodstreamInfections.”
October 15, 2025
UNC Hem/Onc Fellow Sam Short, MD and collaborators/mentors from the REGARDS study published two papers in JTH about stroke risk in atrial fibrillation. Improving stroke risk prediction in atrial fibrillation with circulating biomarkers: the CHA2DS2-VASc–Biomarkers model (DOI: 10.1016/j.jtha.2025.06.007) Circulating biomarkers and ischemic stroke risk in adults with atrial fibrillation taking anticoagulation: the Reasons for Geographic And Racial …
October 3, 2025
Karin Leiderman, PhD and Dougald Monroe, PhD published in JTH. Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions. This study aimed to investigate emicizumab’s lipid-surface dependent mechanisms through mathematical modeling and biochemical assays. Read more here
September 25, 2025
Erica Sparkenbaugh, PhD appointed the co-chair of the 2029 HTRS Scientific Symposium Planning Committee We are excited to announce the Planning Committee for the HTRS 2027 Scientific Symposium, a dynamic three-day scientific conference dedicated to the advancement of clinical, translational, and discovery-based science research related to disorders of hemostasis and thrombosis. Meet …
September 11, 2025
Dr Monroe and colleagues published a study on the role of plasma inhibitors in regulating thrombin levels. Dougald Monroe, professor in the UNC Division of Hematology, and colleagues Allen Ma and Maureane Hoffman published their study on the contribution of four plasma inhibitors in regulating thrombin generation. The work was published in Blood Vessels, Thrombosis, …
August 14, 2025
View BRC August 2025 Newsletter August 2025 Newsletter
August 7, 2025
Matthew Karafin published the initial results of his prospective randomized clinical trial in JCI. Authors: Matthew S. Karafin, Abby S. Grier, Ross M. Fasano, Anton Ilich, David Wichlan, Ada Chang, Sonjile M. James, Hailly E. Butler, Oleg Kolupaev, Melissa C. Caughey, Daniel Stephenson, Julie A. Reisz, Nigel S. Key, Joshua J. Field, Jane A. Little, Steven L. Spitanik, …
July 30, 2025
Please join us for our Fall 2025 Blood Research Center Seminar Series, happening at 11am. Follow us on Linkedin for more information
July 25, 2025
Kylie Hutchison, a rising 2nd year PhD student within the Pathobiology and Translational Science program, was accepted into the UNC Certificate Program in Translational Medicine and selected as 1 of 4 trainees to receive funding from the certificate’s T32 training grant from the National Institute for General Medical Sciences (NIGMS) (NIH T32GM122741). This certificate program provides specialized …
June 10, 2025
Published article in Biophys Journal: Modeling platelet P2Y1/12 pathway to integrin activation. Authors: Patel KB, Bergmeier W, Fogelson AL.