News Archives | Page 3 of 9 | UNC Blood Research Center

In the NIH-funded ‘American Trial Using Tranexamic Acid in Thrombocytopenia (A-TREAT)’ trial, UNC was one of 3 participating clinical centers to enroll patients with platelet transfusion-dependence due to therapy for hematologic malignancies. Between 2016 and 2020, 337 patients were randomized in a double blind fashion to tranexamic acid (TXA) or placebo. Ultimately, no benefit of …

Matthew Flick, PhD was recently awarded a NIH U01 grant, which is part of the Pancreatic Ductal Adenocarcinoma (PDAC) Stromal Reprogramming Consortium (PSRC). This is an MPI award that Dr. Flick received with collaborators Bumsoo Han, PhD at Purdue University and Melissa Fishel, PhD at the Indiana University School of Medicine. The title of the …

Drs. Raj Kasthuri and Yara Park of the UNC BRC, along with multiple alumni of the UNC hematology and transfusion medicine fellowships, co-authored a multi-institutional investigation into the role of race in the response of TTP patients to rituximab that has been accepted for publication in Blood. The study included 645 TTP patients from …

photo of matthew karafin, smiling in a suit

The focus of the grant is to investigate red blood cell alloimmunization risk using the REDS-III databases. Red blood cell (RBC) alloimmunization is a leading cause of morbidity and mortality in transfusion and pregnancy settings, resulting in hemolytic reactions and other adverse sequelae such as hemolytic disease of the fetus and newborn. Alloimmunization occurs in …

Dr. Patrick Ellsworth has been awarded the Access to Insight 2022 Basic Research Grant, totaling 63,000 Euros! This was a competitive grant with international applicants. Dr. Ellsworth’s project is titled “Mechanistic Investigation of Factor IX/IXa Synergy with Emicizumab” and he will be working with Dr. Monroe here of the BRC and Dr. Maureane Hoffman at Duke …

Effective July 1, 2022, Dr. Alisa Wolberg began service as the new Chair of the Hemostasis, Thrombosis, Blood Cells, and Transfusion study section of the NHLBI. She will serve a 2-year term in this role. Congratulations, Dr. Wolberg!

“A gene therapy clinical trial for hemophilia shows promise and could be approved by the FDA later this year — a feat made possible, in part, by UNC-Chapel Hill’s 70-year-old research program.” Click here to read the article.

Research performed at the BRC will be well represented at the 30th Congress of the International Society on Thrombosis and Haemostasis meeting in London, UK from July 9-13. A list of scheduled oral presentations and posters is included at this link.

Erica Sparkenbaugh, PhD, has been awarded a NC TRaCS $2K Pilot Grant for her study “Evaluation of Pre-thrombotic Markers in Female Patients with Sickle Cell Disease on Hormonal Contraception”. Congrats, Erica!

Woosuk Steve Hur, a postdoctoral fellow in the Flick Lab, has been awarded a Canadian Institutes of Health Research (CIHR) Postdoctoral Fellowship. This award covers salary support and provides funds for travel for 2 years.

Katharine King, a third year undergraduate from the biology department working in Dr. Flick’s lab, gave an invited oral presentation at the Nutrition and Obesity Research Center (NORC) Symposium last week. Her presentation was entitled: “Elimination of fibrin(ogen)-aMb2-binding function, but not fibrinogen deficiency, protects against obesity and metabolic syndrome” Katie won the undergraduate student oral …

On April 1st, 2022, Nigel Mackman, PhD presented the inaugural J. Evans Sadler Lectureship – ‘Mechanisms of Cancer-Associated Thrombosis’

Category: News

BRC Investigators Publish Results of Randomized Trial of Anti-Fibrinolytic Therapy and Ancillary Laboratory Study in ‘Blood’ and ‘Blood Advances’

Matt Flick, Ph.D. Awarded NIH U01 Grant

Raj Kasthuri, MD and Yara Park, MD Published in Blood, “Race, Rituximab, and Relapse in TTP”

Matt Karafin, MD is a Collaborating Investigator on a Recently Awarded Multi-Institution R21 Grant From the NIH-NHBLI

Patrick Ellsworth, MD Awarded Research Grant

Alisa Wolberg, PhD New Chair of HTBT Study Section

UNC Contribution to Gene Therapy in Hemophilia Highlighted by Endeavors Magazine

Blood Research Center Members to Present Their Research at Upcoming ISTH Meeting

Erica Sparkenbaugh, PhD Awarded NC TRaCS $2K Pilot Grant

Woosuk Steve Hur, PhD Awarded a Canadian Institutes of Health Research (CIHR) Postdoctoral Fellowship

Katharine King Wins Undergraduate Student Oral Presentation Award

Nigel Mackman, PhD Presented the Inaugural J. Evan Sadler Lectureship