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Steven Grover, PhD has been awarded an R01 from NIH NHLBI in the amount of $3,275,000 for a five-year project titled “Regulation of Coagulation and Thrombosis by C1-inhibitor”. The award will fund translational studies to evaluate the procoagulant phenotype associated with congenital C1-inhibitor deficiency and the potential utility of FDA...

August 2024 Newsletter

The new MPI R01 from the NIH NHLBI, entitled “Role of Factor XII in Thrombo-Inflammatory Complications of Sickle Cell”, was awarded to Rafal Pawlinski, PhD of University of North Carolina at Chapel Hill and to Evi Stavrou, MD of Case Western Reserve University. The four-year $3,129,000 project is proposed to...

“Blood coagulation factor IX: structural insights impacting hemophilia B therapy” was recently accepted for publication in the journal Blood. The work is a collaboration between BRC Center member Dougald Monroe and Leiden University Medical Center investigators Rianne Elaine van Diest and Mettine H A Bos. This review focuses on analyzing...

Yohei Hisada, Ph.D. awarded SOM Boost funding award from the Dean’s office. The Dean’s Office will provide proposal Mechanisms of coagulopathy and bleeding in acute promyelocytic leukemia with Boost funding. The Boost award will provide $25,000 to help sustain his project and obtain preliminary data during the resubmission and review...

The International Society on Thrombosis and Haemostasis (ISTH), an international medical and scientific professional Society advancing the understanding, prevention, diagnosis, and treatment of thrombosis and hemostasis, announces the ISTH 2024 Congress will be hosted in Bangkok, Thailand for the first time on June 22-26, 2024, at the Queen Sirikit National...

Melissa Caughey PhD received an NIH grant related to sickle cell disease: “Chronic dehydration in sickle cell disease: an actionable biomarker to prevent vaso-occlusive episodes” The National Institutes of Health is the largest public funder of biomedical research in the world. In fiscal year 2022, NIH invested most of its...

A manuscript entitled “Disease severity drives thrombosis risk in women with sickle cell disease in a single-center retrospective study” was recently accepted in Research and Practice in Thrombosis and Haemostasias. The research was initiated by Jennifer Light, MD, during her fellowship in the UNC Pediatrics Division of Hematology and Oncology....

A new MPI NIH R01 was awarded to Alisa Wolberg, PhD and Karin Leiderman, PhD of University of North Carolina at Chapel Hill School of Medicine, entitled: “Interdisciplinary Approach to Elucidate Modifiers of Bleeding Phenotype in Factor XI Deficiency.” PROJECT SUMMARY Congenital deficiency of plasma clotting factor (F)XI is an autosomal disorder. Whereas some individuals...

Jamie Madrigal, Mac Monroe, Suzanne Sindi, Karin Leiderman, from The University of North Carolina at Chapel Hill School of Medicine, had a new paper published in Mathematical Biosciences. “Modeling the Distribution of Enzymes on Lipid Vesicles: A Novel Framework for Surface-Mediated Reactions in Coagulation”. Abstract Blood coagulation is a network...

Abigail Ballard-Kordeliski, Robert H. Lee, Ellen Clelia O’Shaughnessy, Paul Y. Kim, Summer R Jones, Rafal Pawlinski, Matthew J. Flick, David S. Paul, Nigel Mackman, David Adalsteinsson, Wolfgang Bergmeier all of University of North Carolina at Chapel Hill had their research published in the journal Blood.   Title: “4D intravital imaging...

May 2024 Newsletter