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Office: 538 EPA Building
Phone: 919-966-0770
Fax: 919-966-9863
Email: mhazucha@med.unc.edu

Dr. Milan J. Hazucha is a Research Professor of Medicine in the Department of Medicine, School of Medicine and a Senior Research Scientist in the Center for Environmental Medicine, Asthma and Lung Biology (CEMALB), University of North Carolina at Chapel Hill. He received his MD in 1962 from Comenius University, Bratislava, Slovakia and his PhD in 1974 from McGill University, Montreal, Canada.

The primary area of his research has been the health effects of air pollutants on healthy and at-risk population such as children, asthmatics and individuals with chronic lung disease. The studies has focused on elucidation of physiologic mechanisms induced by short-term and prolonged controlled laboratory exposures of volunteers to ozone, SO2, NO2, CO and PM. The primary endpoints of response to inhalation of these pollutants have been acute lung function impairment, cardiovascular and airway inflammatory effects, the fields in which he has an extensive experience and published expertise. Over the past 30 years he has been either Principal Investigator or Co-Investigator in numerous collaborative laboratory, clinical and field exposure studies with CEMALB and EPA Human Studies Division (HSD) investigators and jointly received several scientific awards.

 

Papers (last 5 years)

1. Samet JM, Rappold A, Graff D, Cascio WE, Berntsen JH, Huang YC, Herbst M, Bassett M, Montilla T, Hazucha MJ, Bromberg PA, Devlin RB... Concentrated Ambient Ultrafine Particle Exposure Induces Cardiac Changes in Young Healthy Volunteers. Am J Respir Crit Care 179:1034-1042, 2009.

  1. Zhou H., X. Wang, L. Brighton, M. Hazucha, I. Jaspers, and J.L. Carson. Increased Nasal Epithelial Ciliary Beat Frequency Associated With Lifestyle Tobacco Smoke Exposure. Inhal Toxicol. 21/8:875-881, 2009.
  2. Lie H, MA Zariwala, AM Bowcock, JL Carson, DE Brown III, MJ Hazucha, J Forsen, D Molter, MR Knowles, MW Leigh, TW Ferkol. Primary ciliary dyskinesia in Amish communities. J Pediatr 156:1023-1025, 2010.
  3. Carson JL, Lu T-S, Brighton L, Hazucha M, Jaspers I, Zhou H. Phenotypic and physiologic variability in nasal epithelium cultured from smokers and non-smokers exposed to secondhand tobacco smoke. In Vitro Cell Dev Biol Anim. 46:606-612, 2010.
  4. Lefohn, A.S., M. J. Hazucha, D. Shadwick, W. C. Adams. An Alternative Form and Level of the Human Health Ozone Standard. Inhal Toxicol 22:999-1011, 2010.
  5. Alexis NE, Lay JC, Hazucha M, Harris B, Hernandez ML, Bromberg PA, Kehrl H, Diaz-Sanchez D, Kim C, Devlin RB, Peden DB. Low-level ozone exposure induces airways inflammation and modifies cell surface phenotypes in healthy humans. Inhal Toxicol 22:593-600, 2010.
  6. Kim C.S., N. E. Alexis, A. G. Rappold, H. Kehrl, M. J. Hazucha, J. C. Lay, M. Schmitt, M. Case, R. B. Devlin, D. B. Peden, and D. Diaz-Sanchez. Lung Function and Inflammatory Responses in Healthy Young Adults Exposed to 0.06 ppm Ozone for 6.6 Hours. Am J Respir Crit Care Med , 183:1215-1221, 2011.
  7. Zhou, H., B. Zou, M. Hazucha, and J. L. Carson. Nasal Nitric Oxide and Lifestyle Exposure to Tobacco Smoke. Ann Oto Rhino Laryngol, 120:455-459, 2011.
  8. Knowles MR, Leigh MW, Carson JL, Davis SD, Dell SD, Ferkol TW, Olivier KN, Sagel SD, Rosenfeld M, Burns KA, Minnix SL, Armstrong MC, Lori A, Hazucha MJ, Loges NT, Olbrich H, Becker-Heck A, Schmidts M, Werner C, Omran H, Zariwala MA; for the Genetic Disorders of Mucociliary Clearance Consortium. Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure. Thorax 67:433-441; 2012.
  9. Ostrowski L.E., D. Stewart, and M. Hazucha. Interferon γ stimulates accumulation of gas phase nitric oxide in differentiated cultures of normal and cystic fibrosis airway epithelial cells. Lung 190(5):563-571, 2012.
  10. Knowles MR, MW Leigh, LE Ostrowski, L Huang, JL Carson, MJ Hazucha, W Yin, JS Berg, SD Davis, SD Dell, TW Ferkol, M Rosenfeld, SD Sagel, CE Milla, KN Olivier, EH Turner, AL Mackenzie, M Bamshad, DA Nickerson, J Shendure, MA Zariwala, and the Genetic Disorders of Mucociliary Clearance Consortium. Exome Sequencing Identifies Mutations in CCDC114 as a Cause of Primary Ciliary Dyskinesia. Am J Human Genetics 92:99-106, 2013.
  11. Daniels MLA, Leigh MW, Davis SD, Armstrong MC, Carson JL, Hazucha M, Dell SD, Eriksson M, Collins FS, Knowles MR, Zariwala MA. Founder Mutation in RSPH4A Identified in Patients of Hispanic Descent with Primary Ciliary Dyskinesia. Hum Mut 34:1352-1356, 2013.
  12. Alexis NE, Lay JC, Zhou H, Kim CS, Hernandez ML, Kehrl H, Hazucha MJ, Devlin RB, Diaz-Sanchez D, Peden DB. The Glutathione-S-Transferase null genotype and increased neutrophil response to low level ozone (0.06 ppm). JACI 131:610-612, 2013.
  13. Ferkol TW, Puffenberger EG, Lie H, Helms C, Strauss KA, Bowcock A, Carson JL, Hazucha MJ, Morton DH, Patel A, Leigh MW, Knowles MR, and Zariwala M. Primary ciliary dyskinesia-causing mutations in Amish and Mennonite communities. J Ped 163:383-387, 2013.
  14. Knowles MR, LE Ostrowski, NT Loges, T Hurd, MW Leigh, L Huang,WE Wolf, JL Carson, MJ Hazucha, W Yin, SD Davis, SD Dell, TW Ferkol, SD Sagel, KN Olivier, C Jahnke, H Olbrich, C Werner, J Raidt, J Wallmeier, P Pennekamp, GW Dougherty, R Hjeij, H Yung Gee, EA Otto, J Halbritter, M Chaki, K Diaz, DA Braun, JD Porath, M Schueler, G Baktai, M Griese, EH Turner, AP Lewis, MJ Bamshad, DA Nickerson, F Hildebrandt, J Shendure, H Omran, MA Zariwala. Mutations in SPAG1 Cause Primary Ciliary Dyskinesia Associated with Defective Outer and Inner Dynein Arms. Am J Human Genet 93:1-10, 2013.
  15. Hazucha, MJ., J Lay, W Bennett., K Zeman, N Alexis, H Kehrl, A Rappold, PA Bromberg, W E Cascio and RB Devlin. Pulmonary function response in current smokers and ex-smokers following exposure to concentrated fine ambient air particles. Particle Fibre Toxicol 10:58, 2013.
  16. Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Brown DE, LaVange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Rosenfeld M, Milla C, Lee H-S, Krischer J, Zariwala MA, Knowles MR: Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia, Ann Am Thorac Soc, 2013 Dec;10(6):574-81 (PMID: 24024753)
  17. Shapiro A, S Davis, T Ferkol, S Dell, M Rosenfeld, K Olivier, S Sagel, C Milla, MA Zariwala, W Wolf, JL Carson, MJ Hazucha, K Burns, B Robinson, M Knowles, and M Leigh for the Genetic Disorders of Mucociliary Clearance Consortium. Laterality Defects other than Situs Inversus Totalis in Primary Ciliary Dyskinesia: Insights into Situs Ambiguus and Heterotaxy. (Accepted in Chest).
  18. Knowles MR, LE Ostrowski, MW Leigh, PR Sears, SD Davis, WE Wolf, MJ Hazucha, JL Carson, KN Olivier, SD Sagel, M Rosenfeld, TW Ferkol, SD Dell, CE Milla, SH Randell, W Yin, A Sannuti, HM Metjian, PG Noone, PJ Noone, DA Olson, MV Patrone, H Dang, Genetic Disorders of Mucociliary Clearance Consortium Team, NHLBI GO Exome Sequencing Project and Family Studies Project Team, H-S Lee, TW Hurd, HY Gee, EA Otto, J Halbritter, S Kohl, M Kircher, J Krischer, MJ Bamshad, DA Nickerson, F Hildebrandt, J Shendure, MA Zariwala. Mutations in RSPH1 Cause Primary Ciliary Dyskinesia with a Unique Clinical and Ciliary Phenotype. Am J Respir Crit Care Med , 189: , 2014.
  19. Davis SD, TW Ferkol, M Rosenfeld, HS Lee, SD Dell, SD Sagel, C Milla, MA Zariwala, J Pittman, AJ Shapiro, JL Carson, J Krischer, MJ Hazucha, ML Cooper, MR Knowles, MW Leigh. Clinical Features of Childhood Primary Ciliary Dyskinesia: By Genotype and Ultrastructural Phenotype. Am J Respir Crit Care Med , 189: , 2014.

 

Selected Chapters/Reviews:

1. Hazucha, M.J., J.F. Ginsberg, W.F. McDonnell, E.D. Haak, J.L. Pimmel, D.E. House, and P.A. Bromberg. Changes in Bronchial Reactivity of Asthmatics and Normals Following Exposures to 0.1 ppm NO2. In: Air Pol­lution by Nitrogen Oxides, Vol.21, Schneider,T.l., Grant,R., eds., Elsevier Publ.Co., Amsterdam, p. 387-400, 1983.

2. Kehrl, H.R., M.J. Hazucha, J. Solic, and P.A. Bromberg. The Acute Ef­fects of 0.2 and 0.3 ppm ozone in persons with Chronic Obstructive Lung Disease (COLD). In: “Advances in Modern Environmental Toxicology”, Mehlman, M.A., Lee S.D., Mustafa, M.G., (eds.) Princeton Sci. Pub. Inc., Princeton, N.J., pp 213-225, 1983.

3. McDonnell, W.F., D.H. Horstman, M.J. Hazucha, E. Seal, E.D. Haak, Jr., S.A. Salaam, and E.D. House. Pulmonary Response during Exposure to Low concentrations of Ozone Exposure Upon pulmonary Function. In: “Advances in Modern Environmental Toxicology”, Mehlman, M.A., Lee S.D., Mustafa, M.G.,(eds.), Princeton Sci. Pub. Inc., Princeton, N.J.,pp.139-144, 1983.

4. Folinsbee, L.J., and M.J. Hazucha. Persistence of Ozone-Induced Changes in Lung Function and Airway Reactivity. In: “Atmospheric Ozone Research and its Policy Implications”. T. Schneider et al., eds., Elsevier Publ., Amsterdam, pp. 483-492, 1989.:

5. Hazucha, M.J. Meta-analysis and “effective dose” revisited. In: Advances in Controlled Clinical Inhalation Studies, 3rd International Inhalation Symposium, October 1991, Mohr, U., Ed.-in-Chief, Springer-Verlag, Berlin, pp. 247-256, 1993.

6. Hazucha, M.J. Health effects due to interaction of nitrogen oxides and ozone. In “Health effects of ozone and nitrogen oxides in an integrated assessment of air pollution.” Inst. for Environment and Health, Publ., Leicester, UK, 1997, pp.42-52.

7. Hazucha, M.J. and D. Pankow. Toxicokinetics and Metabolism. In:Environmental Health Criteria 213, Carbon Monoxide, Chen, Q. and J. Raub, eds., WHO/IPCS Task Group, WHO Geneva, 1999, chap. 6, pp. 134-161.

8. Hazucha,M.J. Controlled Exposures to Ozone , Nitrogen Oxides and Acids.In: “Air Pollution and Health.” Holgate, S.T., et al., eds., Academic Press, London, 1999, chap. 23, pp. 511-529.

9. Hazucha, M.J.. Effect of carbon monoxide on work and exercise capacity in humans. In:” Carbon Monoxide Toxicity”, D. G. Penney, ed., CRC Press, 2000, chap. 5, pp.101-134.

10. Cascio WE, Hazucha MJ, Stone SL, Devlin RB. Cardiovascular Effects of Air Pollutants. In Netter’s Cardiology. 2nd Edition. Chapter 75, pages 627-631, 2010. Eds. MS Runge, MS, C Patterson, and GA Stoeffer, Saunders/Elsevier Inc. Philadelphia, PA, 2010, ISBN 978-1-4377-0637-6; ISBN on-line 978-1-4377-0638-3