David Peden, Ph.D
My research focuses on translational studies of the human inflammatory and physiologic response to pollutants, development of interventions for adverse effects of air pollutants, and novel interventions for asthma. Methods we employ include: 1.) Use of controlled exposures to pollutants (Phase I-II studies) to define inflammatory response to pollutants and identification of biological determinants of response and to undertake proof of concept studies of interventions to mitigate the effect of these pollutants; 2.) Use of electronic health records to explore the effect of environmental factors on a wide variety of health outcomes, including chronic disease exacerbation and impact on episodic health events such as COVID-19 or wildfire events; 3.) Testing novel interventions for asthma. This effort includes assessment of interventions for increased airway clearance and as the medical monitor of the NHLBI-funded PreCISE asthma network for which UNC serves as the Data, Modeling and Coordination Center; and 4.) Lead PI of the UNC Health asymptomatic seroprevalence study for IgG antibody response for SARS-CoV2. This dataset will be used to assess biologic response to SARS-CoV2 and environmental impacts on this response.
Heather Wells, Research Specialist
Jamie Antinori, Research Technician
Isabela DeJohn, Work Study
Jessica Chlebowski, Work Study
Markus Parson, Work Study