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Biochemistry and biophysics PhD student, Cathy Spangler, researches in Robert McGinty’s lab and recently published a paper in collaboration with Joshua Boyer, Joshua Strauss, Andrew Cesmat, Pengda Liu, Robert McGinty, and Qi Zhang, titled Structural basis of nucleosome-dependent cGAS inhibitionThis article addresses the use of cryo-electron microscopy to determine the high-resolution structure of a DNA-sensing protein called cGAS bound to the nucleosome – the fundamental repeating unit of chromatin.

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