Skip to main content

UNC’s Cryo-EM Core facility develops new methodology for high-speed, high-resolution cryogenic electron microscopy technology

February 8, 2022

Dr. Jonathan Fay, in collaboration with Jared Peck and Dr. Joshua Strauss of the UNC CH CryoEM Core, published a method paper in IUCrJ (International Union of Crystallography Journal) outlining their success in optimizing the function of a microscope for cryogenic electron microscopy (CryoEM). CryoEM is an imaging technique that yields 3D structures of large macromolecular complexes, … Continued

Researchers Reveal Structure of Itch Receptors on Cells

November 17, 2021

Ever wonder what’s going on when you get itchy skin, whether from a rash or medication or some other bodily reaction? And why do some strong anti-itching medications make us nauseous, dry-mouthed zombies? Scientists at the UNC School of Medicine and the University of California at San Francisco conducted research showing in precise detail how … Continued

Graduate Student Cathy Spangler in McGinty lab uses cryo-EM to determine structure of cGAS

October 6, 2020

Biochemistry and biophysics PhD student, Cathy Spangler, researches in Robert McGinty’s lab and recently published a paper in collaboration with Joshua Boyer, Joshua Strauss, Andrew Cesmat, Pengda Liu, Robert McGinty, and Qi Zhang, titled Structural basis of nucleosome-dependent cGAS inhibition. This article addresses the use of cryo-electron microscopy to determine the high-resolution structure of a DNA-sensing protein called cGAS bound … Continued

Duke, UNC and NIEHS host first ever Triangle Area Cryo-Symposium

December 19, 2019

For two days (December 16-17, 2019) Structural Biologists, from across the Piedmont, attended the first ever 2019 Triangle Area Cryo-EM Symposium in Durham, NC. The event, funded in part by an Interdisciplinary Colloquium Grant from the Duke School of Medicine, allowed researchers from Duke University, North Carolina University at Chapel Hill and the National Institute … Continued

Researcher Kathryn Gunn relies on Research Computing

August 8, 2019

Kathryn Gunn is a post-doctoral researcher in the Neher Lab of the Biochemistry and Biophysics Department within the UNC-Chapel Hill School of Medicine. She is a new client of ITS Research Computing. Read more!

The CryoEM Revolution has Arrived

May 16, 2019

Installation of a Thermo Scientific Talos Arctica 200 Kv cryo-transmission electron microscope (cryo-TEM) is nearly complete in the Glaxo Research Building at the University of North Carolina at Chapel Hill. Once functioning this summer, this $3-million instrument will bring exciting new capabilities to researchers across the university and others in the RTP area. Read more!

UNC scientists solve 3-D structure of CF protein in active, inactive states

October 18, 2018

The labs of John Riordan at the UNC School of Medicine Biochemistry and Biophysics and James Chen at Oregon Health & Science University published detailed cryo-electron microscopic analysis of the CFTR protein to gain insights into why a faulty chloride channel leads to serious disease. Read more!