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Center for Structural Biology

Rigor and Reproducibility

UNC CryoEM Core Rigor and Reproducibility Commitment

The CryoEM Core is committed to providing researchers advice, training, access to equipment, and services for high-resolution cryoEM.  There are several ways we contribute to scientific rigor and reproducibility.

  • The microscope is routinely maintained, aligned, and benchmarked with a biological sample to ensure data quality.
  • Data collected on the microscope is processed on-the-fly to assess data quality. The raw and pre-processed data is provided to researchers.
  • Equipment used for specimen preparation is maintained, tested, and benchmarked with a biological sample to ensure it is in working order.
  • If we notice an error or malfunction in the equipment, microscope, or software that compromises data quality, we will contact those affected and work to fix the problem as quickly as possible.
  • We provide SOPs for the operation of CryoEM Core equipment, including the Vitrobot and Talos Arctica.
  • A CryoEM Core Staff member is on-site during normal working hours and available to assist users if they require help.
  • We offer training for the electron microscope and specimen preparation for single-particle cryoEM.
  • We offer assistance in grant writing, and for preparing the method section of a scientific paper.
  • We offer assistance in project planning and consultation for researchers interested in starting a cryoEM project.