Department of Genetics Publications August 22nd – September 4th 2021

Department of Genetics faculty, postdocs, students and collaborators published 9 papers during August 22^nd – September 4^th 2021.

 

SnapHiC: a computational pipeline to identify chromatin loops from single-cell Hi-C data. 

Yu M, Abnousi A, Zhang Y, Li G, Lee L, Chen Z, Fang R, Lagler TM, Yang Y, Wen J, Sun Q, Li Y, Ren B, Hu M.

Nat Methods. 2021 Aug 26. doi: 10.1038/s41592-021-01231-2. Online ahead of print.

PMID: 34446921

 

ExpressHeart: Web Portal to Visualize Transcriptome Profiles of Non-Cardiomyocyte Cells. 

Li G, Luan C, Dong Y, Xie Y, Zentz SC, Zelt R, Roach J, Liu J, Qian L, Li Y, Yang Y.

Int J Mol Sci. 2021 Aug 19;22(16):8943. doi: 10.3390/ijms22168943.

PMID: 34445647

 

Eukaryotic phosphatase inhibitors enhance colistin efficacy in gram-negative bacteria. 

Barker WT, Jania LA, Melander RJ, Koller BH, Melander C.

Chem Biol Drug Des. 2020 Nov;96(5):1180-1186. doi: 10.1111/cbdd.13735. Epub 2020 Jun 19.

PMID: 32562384

 

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. 

Cade BE, Lee J, Sofer T, Wang H, Zhang M, Chen H, Gharib SA, Gottlieb DJ, Guo X, Lane JM, Liang J, Lin X, Mei H, Patel SR, Purcell SM, Saxena R, Shah NA, Evans DS, Hanis CL, Hillman DR, Mukherjee S, Palmer LJ, Stone KL, Tranah GJ; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium (Li Y, Raffield L), Abecasis GR, Boerwinkle EA, Correa A, Cupples LA, Kaplan RC, Nickerson DA, North KE, Psaty BM, Rotter JI, Rich SS, Tracy RP, Vasan RS, Wilson JG, Zhu X, Redline S; TOPMed Sleep Working Group.

Genome Med. 2021 Aug 26;13(1):136. doi: 10.1186/s13073-021-00917-8.

PMID: 34446064

 

Naturalistic Stress Hormone Levels Drive Cumulative Epigenomic Changes along the Cellular Lifespan. 

Zannas AS.

Int J Mol Sci. 2021 Aug 16;22(16):8778. doi: 10.3390/ijms22168778.

PMID: 34445485

 

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs. 

Akhtari FS, Green AJ, Small GW, Havener TM, House JS, Roell KR, Reif DM, McLeod HL, Wiltshire T, Motsinger-Reif AA.

PLoS Genet. 2021 Aug 26;17(8):e1009732. doi: 10.1371/journal.pgen.1009732. Online ahead of print.

PMID: 34437536

 

Phase II Study of Gemcitabine and Split-Dose Cisplatin Plus Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Bladder Cancer. 

Rose TL, Harrison MR, Deal AM, Ramalingam S, Whang YE, Brower B, Dunn M, Osterman CK, Heiling HM, Bjurlin MA, Smith AB, Nielsen ME, Tan HJ, Wallen E, Woods ME, George D, Zhang T, Drier A, Kim WY, Milowsky MI.

J Clin Oncol. 2021 Aug 24:JCO2101003. doi: 10.1200/JCO.21.01003. Online ahead of print.

PMID: 34428076

 

A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. 

Xu C, Meng F, Park KS, Storey AJ, Gong W, Tsai YH, Gibson E, Byrum SD, Li D, Edmondson RD, Mackintosh SG, Vedadi M, Cai L, Tackett AJ, Kaniskan HÜ, Jin J, Wang GG.

Cell Chem Biol. 2021 Aug 30:S2451-9456(21)00393-7. doi: 10.1016/j.chembiol.2021.08.004. Online ahead of print.

PMID: 34469831

 

P-elements strengthen reproductive isolation within the Drosophila simulans species complex. 

Serrato-Capuchina A, D’Agostino ERR, Peede D, Roy B, Isbell K, Wang J, Matute DR.

Evolution. 2021 Aug 31. doi: 10.1111/evo.14319. Online ahead of print.

PMID: 34463356