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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 10 papers during February 27th – March 12th, 2022.

Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm. 

Liu W, Sun Q, Huang L, Bhattacharya A, Wang GW, Tan X, Kuban KCK, Joseph RM, O’Shea TM, Fry RC, Li Y, Santos HP Jr.

J Neurodev Disord. 2022 Mar 3;14(1):16. doi: 10.1186/s11689-022-09429-x.

PMID: 35240980


Predicting eating disorder and anxiety symptoms using disorder-specific and transdiagnostic polygenic scores for anorexia nervosa and obsessive-compulsive disorder. 

Yilmaz Z, Schaumberg K, Halvorsen M, Goodman EL, Brosof LC, Crowley JJ; Anorexia Nervosa Genetics Initiative; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, Mathews CA, Mattheisen M, Breen G, Bulik CM, Micali N, Zerwas SC.

Psychol Med. 2022 Mar 4:1-15. doi: 10.1017/S0033291721005079. Online ahead of print.

PMID: 35243971


Integration of stakeholder engagement from development to dissemination in genomic medicine research: Approaches and outcomes from the CSER Consortium. 

O’Daniel JM, Ackerman S, Desrosiers LR, Rego S, Knight SJ, Mollison L, Byfield G, Anderson KP, Danila MI, Horowitz CR, Joseph G, Lamoure G, Lindberg NM, McMullen CK, Mittendorf KF, Ramos MA, Robinson M, Sillari C, Madden EB; CSER Stakeholder and Engagement Work Group.

Genet Med. 2022 Feb 25:S1098-3600(22)00024-7. doi: 10.1016/j.gim.2022.01.008. Online ahead of print.

PMID: 35227608


The role of early-life family composition and parental socio-economic status as risk factors for obsessive-compulsive disorder in a Danish national cohort. 

Yilmaz Z, Larsen JT, Nissen JB, Crowley JJ, Mattheisen M, Bulik CM, Petersen LV.

J Psychiatr Res. 2022 Feb 16;149:18-27. doi: 10.1016/j.jpsychires.2022.02.004. Online ahead of print.

PMID: 35219872


Approaches to incorporate extracellular vesicles into exposure science, toxicology, and public health research. 

Carberry CK, Keshava D, Payton A, Smith GJ, Rager JE.

J Expo Sci Environ Epidemiol. 2022 Feb 25. doi: 10.1038/s41370-022-00417-w. Online ahead of print.

PMID: 35217808 Review.


A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia. 

Ren Z, Kim A, Huang YT, Pi WC, Gong W, Yu X, Qi J, Jin J, Cai L, Roeder RG, Chen WY, Wang GG.

Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2122940119. doi: 10.1073/pnas.2122940119.

PMID: 35217626 Free PMC article.


CSB-independent, XPC-dependent transcription-coupled repair in Drosophila

Deger N, Cao X, Selby CP, Gulec S, Kawara H, Dewey EB, Wang L, Yang Y, Archibald S, Selcuk B, Adebali O, Sekelsky J, Sancar A, Liu Z.

Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2123163119. doi: 10.1073/pnas.2123163119.

PMID: 35217627 Free PMC article.


GMEPS: a fast and efficient likelihood approach for genome-wide mediation analysis under extreme phenotype sequencing. 

Liyanage JSS, Estepp JH, Srivastava K, Li Y, Mori M, Kang G.

Stat Appl Genet Mol Biol. 2022 Mar 11;21(1). doi: 10.1515/sagmb-2021-0071.

PMID: 35266368


THUNDER: A reference-free deconvolution method to infer cell type proportions from bulk Hi-C data. 

Rowland B, Huh R, Hou Z, Crowley C, Wen J, Shen Y, Hu M, Giusti-Rodríguez P, Sullivan PF, Li Y.

PLoS Genet. 2022 Mar 8;18(3):e1010102. doi: 10.1371/journal.pgen.1010102. Online ahead of print.

PMID: 35259165


Monetary incentives and peer referral in promoting secondary distribution of HIV self-testing among men who have sex with men in China: A randomized controlled trial. 

Zhou Y, Lu Y, Ni Y, Wu D, He X, Ong JJ, Tucker JD, Sylvia SY, Jing F, Li X, Huang S, Shen G, Xu C, Xiong Y, Sha Y, Cheng M, Xu J, Jiang H, Dai W, Huang L, Zou F, Wang C, Yang B, Mei W, Tang W.

PLoS Med. 2022 Feb 14;19(2):e1003928. doi: 10.1371/journal.pmed.1003928. eCollection 2022 Feb.

PMID: 35157727 Free PMC article. Clinical Trial.