Department of Genetics faculty, postdocs, students and collaborators published fifteen papers during April 4-17, 2021.
Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors.
Ahmed SK, Haese NN, Cowan JT, Pathak V, Moukha-Chafiq O, Smith VJ, Rodzinak KJ, Ahmad F, Zhang S, Bonin KM, Streblow AD, Streblow CE, Kreklywich CN, Morrison C, Sarkar S, Moorman N, Sander W, Allen R, DeFilippis V, Tekwani BL, Wu M, Hirsch AJ, Smith JL, Tower NA, Rasmussen L, Bostwick R, Maddry JA, Ananthan S, Gerdes JM, Augelli-Szafran CE, Suto MJ, Morrison TE, Heise MT, Streblow DN, Pathak AK.
J Med Chem. 2021 Apr 9. doi: 10.1021/acs.jmedchem.0c02183. Online ahead of print.
PMID: 33835811
Johnson BM, Uchimura T, Gallovic MD, Thamilarasan M, Chou WC, Gibson SA, Deng M, Tam JW, Batty CJ, Williams J, Matsushima GK, Bachelder EM, Ainslie KM, Markovic-Plese S, Ting JP.
J Immunol. 2021 Apr 5:ji2001317. doi: 10.4049/jimmunol.2001317. Online ahead of print.
PMID: 33820855
Natarajan P, Pampana A, Graham SE, Ruotsalainen SE, Perry JA, de Vries PS, Broome JG, Pirruccello JP, Honigberg MC, Aragam K, Wolford B, Brody JA, Antonacci-Fulton L, Arden M, Aslibekyan S, Assimes TL, Ballantyne CM, Bielak LF, Bis JC, Cade BE, Do R, Doddapaneni H, Emery LS, Hung YJ, Irvin MR, Khan AT, Lange L, Lee J, Lemaitre RN, Martin LW, Metcalf G, Montasser ME, Moon JY, Muzny D, O’Connell JR, Palmer ND, Peralta JM, Peyser PA, Stilp AM, Tsai M, Wang FF, Weeks DE, Yanek LR, Wilson JG, Abecasis G, Arnett DK, Becker LC, Blangero J, Boerwinkle E, Bowden DW, Chang YC, Chen YI, Choi WJ, Correa A, Curran JE, Daly MJ, Dutcher SK, Ellinor PT, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, He J, Hveem K, Jarvik GP, Kaplan RC, Kardia SLR, Kenny E, Kim RW, Kooperberg C, Laurie CC, Lee S, Lloyd-Jones DM, Loos RJF, Lubitz SA, Mathias RA, Martinez KAV, McGarvey ST, Mitchell BD, Nickerson DA, North KE, Palotie A, Park CJ, Psaty BM, Rao DC, Redline S, Reiner AP, Seo D, Seo JS, Smith AV, Tracy RP, Vasan RS, Kathiresan S, Cupples LA, Rotter JI, Morrison AC, Rich SS, Ripatti S, Willer C; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; FinnGen, Peloso GM.
Nat Commun. 2021 Apr 12;12(1):2182. doi: 10.1038/s41467-021-22339-1.
PMID: 33846329
Konte B, Walters JTR, Rujescu D, Legge SE, Pardiñas AF, Cohen D, Pirmohamed M, Tiihonen J, Hartmann AM, Bogers JP, van der Weide J, van der Weide K, Putkonen A, Repo-Tiihonen E, Hallikainen T, Silva E, Ingimarsson O, Sigurdsson E, Kennedy JL, Sullivan PF, Rietschel M, Breen G, Stefansson H, Stefansson K, Collier DA, O’Donovan MC, Giegling I.
Transl Psychiatry. 2021 Apr 12;11(1):214. doi: 10.1038/s41398-021-01322-w.
PMID: 33846298
Single cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes.
Wang L, Yang Y, Ma H, Xie Y, Xu J, Near D, Wang H, Garbutt T, Li Y, Liu J, Qian L.
Cardiovasc Res. 2021 Apr 11:cvab134. doi: 10.1093/cvr/cvab134. Online ahead of print.
PMID: 33839759
James CA, Jongbloed JDH, Hershberger RE, Morales A, Judge DP, Syrris P, Pilichou K, Medeiros Domingo A, Murray B, Cadrin-Tourigny J, Lekanne Deprez R, Celeghin R, Protonotarios A, Asatryan B, Brown E, Jordan E, McGlaughon J, Thaxton C, Kurtz CL, van Tintelen JP.
Circ Genom Precis Med. 2021 Apr 8. doi: 10.1161/CIRCGEN.120.003273. Online ahead of print.
PMID: 33831308
MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation.
Swahari V, Nakamura A, Hollville E, Stroud H, Simon JM, Ptacek TS, Beck MV, Flowers C, Guo J, Plestant C, Liang J, Kurtz CL, Kanke M, Hammond SM, He YW, Anton ES, Sethupathy P, Moy SS, Greenberg ME, Deshmukh M.
Cell Rep. 2021 Apr 6;35(1):108946. doi: 10.1016/j.celrep.2021.108946.
PMID: 33826889
A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing.
Fan H, Guo Y, Tsai YH, Storey AJ, Kim A, Gong W, Edmondson RD, Mackintosh SG, Li H, Byrum SD, Tackett AJ, Cai L, Wang GG.
Nucleic Acids Res. 2021 Apr 6:gkab210. doi: 10.1093/nar/gkab210. Online ahead of print.
PMID: 33823544
Xu C, Tsai YH, Galbo PM, Gong W, Storey AJ, Xu Y, Byrum SD, Xu L, Whang YE, Parker JS, Mackintosh SG, Edmondson RD, Tackett AJ, Huang J, Zheng D, Earp HS, Wang GG, Cai L.
Nucleic Acids Res. 2021 Apr 13:gkab252. doi: 10.1093/nar/gkab252. Online ahead of print.
PMID: 33849067
Deveson IW, Gong B, Lai K, LoCoco JS, Richmond TA, Schageman J, Zhang Z, Novoradovskaya N, Willey JC, Jones W, Kusko R, Chen G, Madala BS, Blackburn J, Stevanovski I, Bhandari A, Close D, Conroy J, Hubank M, Marella N, Mieczkowski PA, Qiu F, Sebra R, Stetson D, Sun L, Szankasi P, Tan H, Tang LY, Arib H, Best H, Burgher B, Bushel PR, Casey F, Cawley S, Chang CJ, Choi J, Dinis J, Duncan D, Eterovic AK, Feng L, Ghosal A, Giorda K, Glenn S, Happe S, Haseley N, Horvath K, Hung LY, Jarosz M, Kushwaha G, Li D, Li QZ, Li Z, Liu LC, Liu Z, Ma C, Mason CE, Megherbi DB, Morrison T, Pabón-Peña C, Pirooznia M, Proszek PZ, Raymond A, Rindler P, Ringler R, Scherer A, Shaknovich R, Shi T, Smith M, Song P, Strahl M, Thodima VJ, Tom N, Verma S, Wang J, Wu L, Xiao W, Xu C, Yang M, Zhang G, Zhang S, Zhang Y, Shi L, Tong W, Johann DJ Jr, Mercer TR, Xu J; SEQC2 Oncopanel Sequencing Working Group.
Nat Biotechnol. 2021 Apr 12. doi: 10.1038/s41587-021-00857-z. Online ahead of print.
PMID: 33846644
Statistical Modeling of High Dimensional Counts.
Love MI.
Methods Mol Biol. 2021;2284:97-134. doi: 10.1007/978-1-0716-1307-8_7.
PMID: 33835440
Tate AE, Liu S, Zhang R, Yilmaz Z, Larsen JT, Petersen LV, Bulik CM, Svensson AM, Gudbjörnsdottir S, Larsson H, Butwicka A, Kuja-Halkola R.
Diabetes Care. 2021 Apr 6:dc202989. doi: 10.2337/dc20-2989. Online ahead of print.
PMID: 33824142
The awesome power of histone genetics.
Nevil M, Duronio RJ.
Mol Cell. 2021 Apr 15;81(8):1593-1595. doi: 10.1016/j.molcel.2021.03.023.
PMID: 33861947
Stilp AM, Emery LS, Broome JG, Buth EJ, Khan AT, Laurie CA, Wang FF, Wong Q, Chen D, D’Augustine CM, Heard-Costa NL, Hohensee CR, Johnson WC, Juarez LD, Liu J, Mutalik KM, Raffield LM, Wiggins KL, de Vries PS, Kelly TN, Kooperberg C, Natarajan P, Peloso GM, Peyser PA, Reiner AP, Arnett DK, Aslibekyan S, Barnes KC, Bielak LF, Bis JC, Cade BE, Chen MH, Correa A, Cupples LA, de Andrade M, Ellinor PT, Fornage M, Franceschini N, Gan W, Ganesh SK, Graffelman J, Grove ML, Guo X, Hawley NL, Hsu WL, Jackson RD, Jaquish CE, Johnson AD, Kardia SLR, Kelly S, Lee J, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Morrison AC, North KE, Nouraie SM, Oelsner EC, Pankratz N, Rich SS, Rotter JI, Smith JA, Taylor KD, Vasan RS, Weeks DE, Weiss ST, Wilson CG, Yanek LR, Psaty BM, Heckbert SR, Laurie CC.
Am J Epidemiol. 2021 Apr 16:kwab115. doi: 10.1093/aje/kwab115. Online ahead of print.
PMID: 33861317
Improving the completeness of public metadata accompanying omics studies.
Rajesh A, Chang Y, Abedalthagafi MS, Wong-Beringer A, Love MI, Mangul S.
Genome Biol. 2021 Apr 15;22(1):106. doi: 10.1186/s13059-021-02332-z.
PMID: 33858487