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UNC Genetics Publications

Department of Genetics faculty, postdocs, students and collaborators published 12 papers during July 25th – August 7th 2021.


Deep ancestral introgression shapes evolutionary history of dragonflies and damselflies. 

Suvorov A, Scornavacca C, Fujimoto MS, Bodily P, Clement M, Crandall KA, Whiting MF, Schrider DR, Bybee SM.

Syst Biol. 2021 Jul 29:syab063. doi: 10.1093/sysbio/syab063. Online ahead of print.

PMID: 34324671


MHCflurry 2.0: Improved Pan-Allele Prediction of MHC Class I-Presented Peptides by Incorporating Antigen Processing. 

O’Donnell TJ, Rubinsteyn A, Laserson U.

Cell Syst. 2020 Jul 22;11(1):42-48.e7. doi: 10.1016/j.cels.2020.06.010. Epub 2020 Jul 14.

PMID: 32711842


Presence and Transmission of Mitochondrial Heteroplasmic Mutations in Human Populations of European and African Ancestry. 

Liu C, Fetterman JL, Qian Y, Sun X, Blackwell T, Pitsillides A, Cade BE, Wang H, Raffield LM, Lange LA, Anugu P, Abecasis G, Adrienne Cupples L, Redline S, Correa A, Vasan RS, Wilson J, Ding J, Levy D; NHLBI Trans-Omics for Precision Medicine TOPMed Consortium (Li Y).

Mitochondrion. 2021 Jul 21:S1567-7249(21)00097-0. doi: 10.1016/j.mito.2021.07.004. Online ahead of print.

PMID: 34303007


Practical and Ethical Concerns in Implementing Enhanced Surveillance Methods to Improve Continuity of HIV Care: Qualitative Expert Stakeholder Study. 

Buchbinder M, Blue C, Rennie S, Juengst E, Brinkley-Rubinstein L, Rosen DL.

JMIR Public Health Surveill. 2020 Sep 4;6(3):e19891. doi: 10.2196/19891.

PMID: 32886069 Free PMC article.


Limited Association between Schizophrenia Genetic Risk Factors and Transcriptomic Features. 

Yu AW, Peery JD, Won H.

Genes (Basel). 2021 Jul 12;12(7):1062. doi: 10.3390/genes12071062.

PMID: 34356078


Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. 

Wen J, Xie M, Rowland B, Rosen JD, Sun Q, Chen J, Tapia AL, Qian H, Kowalski MH, Shan Y, Young KL, Graff M, Argos M, Avery CL, Bien SA, Buyske S, Yin J, Choquet H, Fornage M, Hodonsky CJ, Jorgenson E, Kooperberg C, Loos RJF, Liu Y, Moon JY, North KE, Rich SS, Rotter JI, Smith JA, Zhao W, Shang L, Wang T, Zhou X, Reiner AP, Raffield LM, Li Y.

Genes (Basel). 2021 Jul 8;12(7):1049. doi: 10.3390/genes12071049.

PMID: 34356065


Hepatocyte growth factor pathway expression in breast cancer by race and subtype. 

Jones GS, Hoadley KA, Olsson LT, Hamilton AM, Bhattacharya A, Kirk EL, Tipaldos HJ, Fleming JM, Love MI, Nichols HB, Olshan AF, Troester MA.

Breast Cancer Res. 2021 Aug 3;23(1):80. doi: 10.1186/s13058-021-01460-5.

PMID: 34344422 Free PMC article.


Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. 

Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P.

Genome Med. 2021 Aug 2;13(1):123. doi: 10.1186/s13073-021-00939-2.

PMID: 34340684 Free PMC article.


T cells protect against hepatitis A virus infection and limit infection-induced liver injury. 

Misumi I, Mitchell JE, Lund MM, Cullen JM, Lemon SM, Whitmire JK.

J Hepatol. 2021 Jul 28:S0168-8278(21)01949-8. doi: 10.1016/j.jhep.2021.07.019. Online ahead of print.

PMID: 34331968


The epidemiology of psychiatric disorders in Africa: a scoping review. 

Greene MC, Yangchen T, Lehner T, Sullivan PF, Pato CN, McIntosh A, Walters J, Gouveia LC, Msefula CL, Fumo W, Sheikh TL, Stockton MA, Wainberg ML, Weissman MM.

Lancet Psychiatry. 2021 Aug;8(8):717-731. doi: 10.1016/S2215-0366(21)00009-2. Epub 2021 Jun 8.

PMID: 34115983 Review.


Genetic underpinnings of regional adiposity distribution in African Americans: Assessments from the Jackson Heart Study. 

Anwar MY, Raffield LM, Lange LA, Correa A, Taylor KC.

PLoS One. 2021 Aug 4;16(8):e0255609. doi: 10.1371/journal.pone.0255609. eCollection 2021.

PMID: 34347846 Free PMC article.


BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion. 

Sofer T, Lee J, Kurniansyah N, Jain D, Laurie CA, Gogarten SM, Conomos MP, Heavner B, Hu Y, Kooperberg C, Haessler J, Vasan RS, Cupples LA, Coombes BJ, Seyerle A, Gharib SA, Chen H, O’Connell JR, Zhang M, Gottlieb DJ, Psaty BM, Longstreth WT Jr, Rotter JI, Taylor KD, Rich SS, Guo X, Boerwinkle E, Morrison AC, Pankow JS, Johnson AD, Pankratz N; NHLBI Trans-Omics for Precision Medicine (TOPMed, Li Y, Raffield L) Consortium, Reiner AP, Redline S, Smith NL, Rice KM, Schifano ED.

HGG Adv. 2021 Jul 8;2(3):100040. doi: 10.1016/j.xhgg.2021.100040. Epub 2021 Jun 12.

PMID: 34337551 Free PMC article.