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UNC Genetics Publications

Department of Genetics faculty, postdocs, students and collaborators published fifteen papers during March 21-April 3, 2021.


Clinical and genomic assessment of PD-L1 SP142 expression in triple-negative breast cancer. 

Ahn SG, Kim SK, Shepherd JH, Cha YJ, Bae SJ, Kim C, Jeong J, Perou CM.

Breast Cancer Res Treat. 2021 Mar 26. doi: 10.1007/s10549-021-06193-9. Online ahead of print.

PMID: 33770313


Gut microbial communities from patients with anorexia nervosa do not influence body weight in recipient germ-free mice. 

Glenny EM, Fouladi F, Thomas SA, Bulik-Sullivan EC, Tang Q, Djukic Z, Trillo-Ordonez YS, A Fodor A, Tarantino LM, M Bulik C, M Carroll I.

Gut Microbes. 2021 Jan-Dec;13(1):1-15. doi: 10.1080/19490976.2021.1897216.

PMID: 33769200


Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication. 

Guo H, Wang Q, Ghneim K, Wang L, Rampanelli E, Holley-Guthrie E, Cheng L, Garrido C, Margolis DM, Eller LA, Robb ML, Sekaly RP, Chen X, Su L, Ting JP.

Nat Immunol. 2021 Mar 25. doi: 10.1038/s41590-021-00898-1. Online ahead of print.

PMID: 33767427


Author Correction: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. 

Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, Coleman JRI, Alloza C, Shen X, Barbu MC, Wigmore EM, Gibson J; 23andMe Research Team, Hagenaars SP, Lewis CM, Ward J, Smith DJ, Sullivan PF, Haley CS, Breen G, Deary IJ, McIntosh AM.

Nat Commun. 2021 Mar 25;12(1):2012. doi: 10.1038/s41467-021-22411-w.

PMID: 33767169


Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses. 

Powers JM, Haese NN, Denton M, Ando T, Kreklywich C, Bonin K, Streblow CE, Kreklywich N, Smith P, Broeckel R, DeFilippis V, Morrison TE, Heise MT, Streblow DN.

PLoS Negl Trop Dis. 2021 Apr 1;15(4):e0009308. doi: 10.1371/journal.pntd.0009308. Online ahead of print.

PMID: 33793555


Actionability of commercial laboratory sequencing panels for newborn screening and the importance of transparency for parental decision-making. 

DeCristo DM, Milko LV, O’Daniel JM, Foreman AKM, Mollison LF, Powell BC, Powell CM, Berg JS.

Genome Med. 2021 Mar 29;13(1):50. doi: 10.1186/s13073-021-00867-1.

PMID: 33781310


Super-hotspots and -coldspots in the repair of UV-induced DNA damage in the human genome. 

Jiang Y, Li W, Lindsey-Boltz LA, Yang Y, Li Y, Sancar A.

J Biol Chem. 2021 Mar 23:100581. doi: 10.1016/j.jbc.2021.100581. Online ahead of print.

PMID: 33771559


Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication. 

Adams LE, Dinnon KH 3rd, Hou YJ, Sheahan TP, Heise MT, Baric RS.

mBio. 2021 Mar 16;12(2):e03149-20. doi: 10.1128/mBio.03149-20.

PMID: 33727353


A molecular subtype of colorectal cancers initiates independently of epidermal growth factor receptor and has an accelerated growth rate mediated by IL10-dependent anergy. 

Mantilla-Rojas C, Yu M, Rinella ES, Lynch RM, Perry A, Jaimes-Alvarado J, Anderson KR, Barba E, Bourgeois EJ, Konganti K, Threadgill DW.

Oncogene. 2021 Mar 25. doi: 10.1038/s41388-021-01752-2. Online ahead of print.

PMID: 33767440


Epigenetic Analysis in Ewing Sarcoma. 

Simon JM, Gomez NC.

Methods Mol Biol. 2021;2226:285-302. doi: 10.1007/978-1-0716-1020-6_22.

PMID: 33326110


DNA polymerase theta suppresses mitotic crossing over. 

Carvajal-Garcia J, Crown KN, Ramsden DA, Sekelsky J.

PLoS Genet. 2021 Mar 22;17(3):e1009267. doi: 10.1371/journal.pgen.1009267. Online ahead of print.

PMID: 33750946


DNA-based screening and personal health: a points to consider statement for individuals and health-care providers from the American College of Medical Genetics and Genomics (ACMG). 

Bean LJH, Scheuner MT, Murray MF, Biesecker LG, Green RC, Monaghan KG, Palomaki GE, Sharp RR, Trotter TL, Watson MS, Powell CM; ACMG Board of Directors.

Genet Med. 2021 Mar 31. doi: 10.1038/s41436-020-01083-9. Online ahead of print.

PMID: 33790423


Super resolution light microscopy of the Drosophila Histone Locus Body reveals a core-shell organization associated with expression of replication dependent histone genes. 

Kemp JP, Yang XC, Dominski Z, Marzluff WF, Duronio RJ.

Mol Biol Cell. 2021 Mar 31:mbcE20100645. doi: 10.1091/mbc.E20-10-0645. Online ahead of print.

PMID: 33788585


On polygenic risk scores for complex traits prediction. 

Zhao B, Zou F.

Biometrics. 2021 Mar 31. doi: 10.1111/biom.13466. Online ahead of print.

PMID: 33786811


Testcrosses are an efficient strategy for identifying cis regulatory variation: Bayesian analysis of allele specific expression (BayesASE). 

Miller BR, Morse AM, Borgert JE, Liu Z, Sinclair K, Gamble G, Zou F, Newman JRB, León-Novelo LG, Marroni F, McIntyre LM.

G3 (Bethesda). 2021 Mar 27:jkab096. doi: 10.1093/g3journal/jkab096. Online ahead of print.

PMID: 33772539