UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published seven papers during September 20 – October 3, 2020.

 

 

  Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. 

Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, Mosley TH, Saba Y, Pirpamer L, Seiler S, Becker JT, Carmichael O, Rotter JI, Psaty BM, Lopez OL, Amin N, van der Lee SJ, Yang Q, Himali JJ, Maillard P, Beiser AS, DeCarli C, Karama S, Lewis L, Harris M, Bastin ME, Deary IJ, Veronica Witte A, Beyer F, Loeffler M, Mather KA, Schofield PR, Thalamuthu A, Kwok JB, Wright MJ, Ames D, Trollor J, Jiang J, Brodaty H, Wen W, Vernooij MW, Hofman A, Uitterlinden AG, Niessen WJ, Wittfeld K, Bülow R, Völker U, Pausova Z, Bruce Pike G, Maingault S, Crivello F, Tzourio C, Amouyel P, Mazoyer B, Neale MC, Franz CE, Lyons MJ, Panizzon MS, Andreassen OA, Dale AM, Logue M, Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Stein JL, Thompson PM, Medland SE; ENIGMA consortium, Sachdev PS, Kremen WS, Wardlaw JM, Villringer A, van Duijn CM, Grabe HJ, Longstreth WT Jr, Fornage M, Paus T, Debette S, Arfan Ikram M, Schmidt H, Schmidt R, Seshadri S.

Nat Commun. 2020 Sep 22;11(1):4796. doi: 10.1038/s41467-020-18367-y.

PMID: 32963231

 

  The Small Protein RmpD Drives Hypermucoviscosity in Klebsiella pneumoniae. 

Walker KA, Treat LP, Sepúlveda VE, Miller VL.

mBio. 2020 Sep 22;11(5):e01750-20. doi: 10.1128/mBio.01750-20.

PMID: 32963003

 

  Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D. 

Viñuela A, Varshney A, van de Bunt M, Prasad RB, Asplund O, Bennett A, Boehnke M, Brown AA, Erdos MR, Fadista J, Hansson O, Hatem G, Howald C, Iyengar AK, Johnson P, Krus U, MacDonald PE, Mahajan A, Manning Fox JE, Narisu N, Nylander V, Orchard P, Oskolkov N, Panousis NI, Payne A, Stitzel ML, Vadlamudi S, Welch R, Collins FS, Mohlke KL, Gloyn AL, Scott LJ, Dermitzakis ET, Groop L, Parker SCJ, McCarthy MI.

Nat Commun. 2020 Sep 30;11(1):4912. doi: 10.1038/s41467-020-18581-8.

PMID: 32999275

 

  Non-Cell-Autonomous Activity of the Hemidesmosomal Protein BP180/Collagen XVII in Granulopoiesis in Humanized NC16A Mice. 

Lin L, Hwang BJ, Li N, Googe P, Diaz LA, Miao E, Vilen B, Thomas NE, Ting J, Liu Z.

J Immunol. 2020 Sep 30:ji2000784. doi: 10.4049/jimmunol.2000784. Online ahead of print.

PMID: 32998984

 

  TWO-SIGMA: A novel two-component single cell model-based association method for single-cell RNA-seq data. 

Van Buren E, Hu M, Weng C, Jin F, Li Y, Wu D, Li Y.

Genet Epidemiol. 2020 Sep 29. doi: 10.1002/gepi.22361. Online ahead of print.

PMID: 32989764

 

  Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism. 

Ramaswami G, Won H, Gandal MJ, Haney J, Wang JC, Wong CCY, Sun W, Prabhakar S, Mill J, Geschwind DH.

Nat Commun. 2020 Sep 25;11(1):4873. doi: 10.1038/s41467-020-18526-1.

PMID: 32978376

 

  Mechanisms underlying the control of dynamic regulatory element activity and chromatin accessibility during metamorphosis. 

Niederhuber MJ, McKay DJ.

Curr Opin Insect Sci. 2020 Sep 23:S2214-5745(20)30106-1. doi: 10.1016/j.cois.2020.08.007. Online ahead of print.

PMID: 32979530