Research Interests
Keywords: chromatin, epigenetics, histone, craniofacial, cancer
The Shpargel laboratory studies the coordination of histone-modifying enzymes in regulating chromatin structure, enhancer activation, and transcription. We utilize mouse genetics and cell culture model systems to study the mechanisms of enhancer activation in neural crest cell epigenetics, craniofacial development, and altered enhancer regulation in cancer. This is accomplished through a variety of techniques including mouse mutagenesis, fluorescent reporters to isolate primary cells of interest, low cell number genomics, and proteomic approaches.
Mentor Training:
- Bias 101
- Faculty Mentoring Workshop for Biomedical Researchers
Training Program Affiliations:
- Genetics and Molecular Biology
Publications
Karl Shpargel in UNC Genetics News
September 9, 2021
Dr. Jason Whitmire awarded DoD Investigator-Initiated Research Award
Jason Whitmire, PhD (Professor, Department of Genetics, Department of Microbiology & Immunology), was awarded a Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award by the US Army Medical Research Acquisition Activity of the Department of Defense (DoD).
August 25, 2021
Karl Shpargel, PhD Awarded New R01 from NIDCR
Dr. Karl Shpargel (Assistant Professor, Genetics) has been awarded a new R01 grant from the National Institute of Dental and Craniofacial Research (NIDCR) for his project titled “Enhancer activation mechanisms in cranial neural crest osteoblast differentiation”.
August 6, 2020
Karl Shpargel, PhD Awarded R56 from NIDCR
Dr. Karl Shpargel (Assistant Professor, Genetics) was awarded an R56 grant from the National Institute of Dental and Craniofacial Research (NIDCR) for his project titled “Enhancer Activation Roles and Mechanisms in Craniofacial Development”.
June 29, 2020
Department of Genetics Publications for June 14-27, 2020
Department of Genetics faculty, postdocs, students and collaborators published nine papers during June 14-27, 2020.
March 23, 2020
Department of Genetics Publications for March 8-21, 2020
Department of Genetics faculty, postdocs, students and collaborators published twelve papers during March 8-21, 2020.
