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Associate Professor, Genetics 

Research Interests

Keywords: chromatin, epigenetics, histone, craniofacial, cancer

The Shpargel laboratory studies the coordination of histone-modifying enzymes in regulating chromatin structure, enhancer activation, and transcription. We utilize mouse genetics and cell culture model systems to study the mechanisms of enhancer activation in neural crest cell epigenetics, craniofacial development, and altered enhancer regulation in cancer. This is accomplished through a variety of techniques including mouse mutagenesis, fluorescent reporters to isolate primary cells of interest, low cell number genomics, and proteomic approaches.

Mentor Training:

  • Bias 101
  • Faculty Mentoring Workshop for Biomedical Researchers

Training Program Affiliations:

  • Genetics and Molecular Biology


Karl Shpargel in UNC Genetics News

Genetics Colloquium_21 0908 Karl Shpargel

August 23, 2021

Wednesday – Department of Genetics Colloquium: Karl Shpargel

UNC Department of Genetics Research Colloquium The UNC Department of Genetics Research Colloquium welcomes Karl Shpargel, Assistant Professor, UNC Department of Genetics on Wednesday, September 8, 2021. Super-enhancer regulation in developmental differentiation and human disorders 1131 Bioinformatics Building and Via Zoom **In person attendees are limited to speakers, speaker labs, and Genetics Department leadership.  This …

Karl Shpargel, PhD