Key words: chromatin and gene regulation, complex traits, inflammatory bowel disease, toxicogenomics, computational biology, single-cell genomics
Chromatin and Gene Regulation
Chromosomes are compacted into increasingly complex chromatin structures within eukaryotic nuclei. High-throughput sequence-based assays have been developed to identify regions of nucleosome-depleted open chromatin that mark all types of regulatory elements genome-wide in tissues and cell-types. The computational integration of these data with related gene expression, transcription factor binding, and epigenetic data provide a more complete picture of the complex process of gene transcription and regulation. With these data, we are also investigating the effects of genetic variation on regulation, as can been seen through allelic imbalance in signal from chromatin and transcription factor data, as well as in quantitative trait loci (QTL)-based analyses of these data across individuals.
Inflammatory Bowel Disease
Inflammatory bowel disease (IBD), primarily consisting of Crohn’s disease and ulcerative colitis, is the result of an inappropriate immune response to the intestinal microbiota in a genetically susceptible individual. We have partnered with Dr. Shehzad Sheikh (Dept of Medicine, CGIBD) and Dr. Praveen Sethupathy (Cornell Univ) to uncover molecular determinants of IBD disease phenotypes. In particular, we hypothesize that changes in gene expression profiles mediated by an altered chromatin landscape in key intestinal cell types such as macrophages, in part influenced by the host genetic background, are significantly contributing to aberrant intestinal inflammation. Using both human tissue and mouse models, we seek to identify where chromatin is altered, the impacts on gene expression, and how these are driven by genetic variation in affected individuals.
Exposure to naturally occurring inhalational toxicants can result in serious health challenges. In particular, exposure to high levels of ozone can trigger or exacerbate serious medical conditions such as asthma and COPD. We hypothesize that ozone exposure can alter normal cellular function through changes to the chromatin architecture and transcriptional profiles in tissues contributing to the onset of health complications. In collaboration with Dr. Samir Kelada (Dept of Genetics), we are investigating the molecular effects of ozone exposure in lungs of genetically diverse mice within the Collaborative Cross mouse resource. Better understanding these effects in mice will provide clues as to how ozone is affecting humans.
- Bias 101
- Center for Faculty Excellence Mentoring Workshop
- Culturally Aware Mentoring (CAM) Workshop
- Faculty Mentoring Workshop for Biomedical Researchers
Training Program Affiliations:
- Bioinformatics and Computational Biology
- Satyaki Roy, Postdoctoral Fellow Email
- Meaghan Kennedy, Graduate Student Email
- Nina Nishiyama, Graduate Student Email
- Michelle Hoffner O’Connor (with Shehzad Sheikh), Graduate Student Email
- Ana Berglind (with Shehzad Sheikh), Graduate Student Email
Terry Furey in UNC Genetics News
August 23, 2021
Department of Genetics Publications August 8th – 21st, 2021
Department of Genetics faculty, postdocs, students and collaborators published 18 papers during August 8th – 21st, 2021.
July 12, 2021
Department of Genetics Publications for June 27 – July 10, 2021
Department of Genetics faculty, postdocs, students and collaborators published 17 papers during June 27 - July 10, 2021.
January 4, 2021
Terry Furey, PhD Appointed Professor
Dr. Terry Furey has been appointed Professor in the Departments of Genetics and Biology, effective Jan. 1, 2021.
June 29, 2020
Department of Genetics Publications for June 14-27, 2020
Department of Genetics faculty, postdocs, students and collaborators published nine papers during June 14-27, 2020.
June 1, 2020
Department of Genetics Publications for May 17-30, 2020
Department of Genetics faculty, postdocs, students and collaborators published eleven papers during May 17-30, 2020.
January 27, 2020
Department of Genetics Publications for Jan. 12-25, 2020
Department of Genetics faculty, postdocs, students and collaborators published seven papers during Jan. 12-25, 2020.
October 9, 2019
Department of Genetics Publications for September 22 – October 5, 2019
Department of Genetics faculty, postdocs, students and collaborators published eleven papers during Sept. 22 – Oct. 5, 2019.
July 9, 2018
Terry Furey, PhD Awarded CEHS Pilot Project
Dr. Terrence Furey, Associate Professor of Genetics, was one of the awardees of the Center for Environmental Health and Susceptibility (CEHS) Pilot Projects Program.
November 7, 2016
Genetics Faculty Publications for Oct 15 – Nov 4, 2016
During the last three weeks, Department of Genetics faculty members, along with their colleagues, have published 21 manuscripts on a wide variety of topics. A survey of current practices for genomic sequencing test interpretation and reporting processes in US laboratories. O’Daniel JM, McLaughlin HM, Amendola LM, Bale SJ, Berg JS, Bick D, Bowling KM, Chao …
August 29, 2016
Terry Furey and Shehzad Sheikh awarded R01 grant from National Institute of Diabetes and Digestive and Kidney Diseases for project titled “Integrative Genetic and Genomic Analyses in the Inflammatory Bowel Diseases”
This project will focus on identifying genetic, regulatory activity, and gene expression changes that significantly contribute to IBD at molecular and clinical levels. Terry Furey, PhD, Associate Professor of Genetics and Biology and Shehzad Sheikh, MD, PhD, Assistant Professor of Medicine and Genetics and Member of the Multidisciplinary Center for IBD Research and Treatment, have …