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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 9 papers during January 21st – February 3rd 2024.

Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population. 

Cruz Cisneros MC, Anderson EJ, Hampton BK, Parotti B, Sarkar S, Taft-Benz S, Bell TA, Blanchard M, Dillard JA, Dinnon KH 3rd, Hock P, Leist SR, Madden EA, Shaw GD, West A, Baric RS, Baxter VK, Pardo-Manuel de Villena F, Heise MT, Ferris MT.

Vaccines (Basel). 2024 Jan 20;12(1):103. doi: 10.3390/vaccines12010103.

PMID: 38276675


Clonal Hematopoiesis and Incident Heart Failure With Preserved Ejection Fraction. 

Schuermans A, Honigberg MC, Raffield LM, Yu B, Roberts MB, Kooperberg C, Desai P, Carson AP, Shah AM, Ballantyne CM, Bick AG, Natarajan P, Manson JE, Whitsel EA, Eaton CB, Reiner AP.

JAMA Netw Open. 2024 Jan 2;7(1):e2353244. doi: 10.1001/jamanetworkopen.2023.53244.

PMID: 38270950


Liver regulatory mechanisms of non-coding variants at lipid and metabolic trait loci. 

Pandey GK, Vadlamudi S, Currin KW, Moxley AH, Nicholas J, McAfee JC, Broadway KA, Mohlke KL.

HGG Adv. 2024 Jan 30:100275. doi: 10.1016/j.xhgg.2024.100275. Online ahead of print.

PMID: 38297830


Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions. 

Kar A, Alvarez M, Garske KM, Huang H, Lee SHT, Deal M, Das SS, Koka A, Jamal Z, Mohlke KL, Laakso M, Heinonen S, Pietiläinen KH, Pajukanta P.

Genome Med. 2024 Jan 31;16(1):19. doi: 10.1186/s13073-024-01291-x.

PMID: 38297378


A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts. 

Whitman ET, Ryan CP, Abraham WC, Addae A, Corcoran DL, Elliott ML, Hogan S, Ireland D, Keenan R, Knodt AR, Melzer TR, Poulton R, Ramrakha S, Sugden K, Williams BS, Zhou J, Hariri AR, Belsky DW, Moffitt TE, Caspi A; Alzheimer’s Disease Neuroimaging Initiative.

Neurobiol Aging. 2024 Jan 24;136:23-33. doi: 10.1016/j.neurobiolaging.2024.01.008. Online ahead of print.

PMID: 38301452


Characterization of the MT-2 Treg-like cell line in the presence and absence of forkhead box P3 (FOXP3). 

McCullough MJ, Tune MK, Cabrera JC, Torres-Castillo J, He M, Feng Y, Doerschuk CM, Dang H, Beltran AS, Hagan RS, Mock JR.

Immunol Cell Biol. 2024 Jan 30. doi: 10.1111/imcb.12725. Online ahead of print.

PMID: 38288547


Linking gene expression to clinical outcomes in pediatric Crohn’s disease using machine learning. 

Chen KA, Nishiyama NC, Kennedy Ng MM, Shumway A, Joisa CU, Schaner MR, Lian G, Beasley C, Zhu LC, Bantumilli S, Kapadia MR, Gomez SM, Furey TS, Sheikh SZ.

Sci Rep. 2024 Feb 1;14(1):2667. doi: 10.1038/s41598-024-52678-0.

PMID: 38302662


The expanded spectrum of human disease associated with GREB1L likely includes complex congenital heart disease. 

Zhao E, Bomback M, Khan A, Krishna Murthy S, Solowiejczyk D, Vora NL, Gilmore KL, Giordano JL, Wapner RJ, Sanna-Cherchi S, Lyford A, Jelin AC, Gharavi AG, Hays T.

Prenat Diagn. 2024 Jan 29. doi: 10.1002/pd.6527. Online ahead of print.

PMID: 38285371


LUSTR: a new customizable tool for calling genome-wide germline and somatic short tandem repeat variants. 

Lu J, Toro C, Adams DR; Undiagnosed Diseases Network; Moreno CAM, Lee WP, Leung YY, Harms MB, Vardarajan B, Heinzen EL.

BMC Genomics. 2024 Jan 26;25(1):115. doi: 10.1186/s12864-023-09935-9.

PMID: 38279154 Free PMC article.